Protein Science and Engineering, Institute of Microbial Technology, Council of Scientific and Industrial Research, Rajasthan, India.
Nucleic Acids Res. 2012 Jan;40(Database issue):D388-93. doi: 10.1093/nar/gkr911. Epub 2011 Oct 28.
ProGlycProt (http://www.proglycprot.org/) is an open access, manually curated, comprehensive repository of bacterial and archaeal glycoproteins with at least one experimentally validated glycosite (glycosylated residue). To facilitate maximum information at one point, the database is arranged under two sections: (i) ProCGP-the main data section consisting of 95 entries with experimentally characterized glycosites and (ii) ProUGP-a supplementary data section containing 245 entries with experimentally identified glycosylation but uncharacterized glycosites. Every entry in the database is fully cross-referenced and enriched with available published information about source organism, coding gene, protein, glycosites, glycosylation type, attached glycan, associated oligosaccharyl/glycosyl transferases (OSTs/GTs), supporting references, and applicable additional information. Interestingly, ProGlycProt contains as many as 174 entries for which information is unavailable or the characterized glycosites are unannotated in Swiss-Prot release 2011_07. The website supports a dedicated structure gallery of homology models and crystal structures of characterized glycoproteins in addition to two new tools developed in view of emerging information about prokaryotic sequons (conserved sequences of amino acids around glycosites) that are never or rarely seen in eukaryotic glycoproteins. ProGlycProt provides an extensive compilation of experimentally identified glycosites (334) and glycoproteins (340) of prokaryotes that could serve as an information resource for research and technology applications in glycobiology.
ProGlycProt（http://www.proglycprot.org/）是一个开放获取、人工 curated 的细菌和古菌糖蛋白综合数据库，其中至少有一个经过实验验证的糖基化位点（糖基化残基）。为了在一个点上提供最大的信息量，该数据库分为两部分：（i）ProCGP-主要数据部分，包含 95 个具有实验特征的糖基化位点的条目，（ii）ProUGP-补充数据部分，包含 245 个具有实验鉴定的糖基化但未特征化的糖基化位点的条目。数据库中的每个条目都进行了充分的交叉引用，并附有关于来源生物体、编码基因、蛋白质、糖基化位点、糖基化类型、附着聚糖、相关寡糖/糖基转移酶（OST/GT）、支持参考文献以及适用的其他信息的可用已发表信息。有趣的是，ProGlycProt 包含多达 174 个条目，对于这些条目，信息不可用或在 Swiss-Prot 2011_07 版中未注释特征化的糖基化位点。该网站支持专门的同源建模结构库和特征化糖蛋白的晶体结构，此外还提供了两个新工具，这些工具是针对原核序列（糖基化位点周围氨基酸的保守序列）的新信息开发的，这些序列在真核糖蛋白中从未出现或很少出现。ProGlycProt 提供了广泛的实验鉴定的糖基化位点（334 个）和糖蛋白（340 个）的汇编，可作为糖生物学研究和技术应用的信息资源。
