Sobel J D, Schmitt C, Meriwether C
Department of Medicine, Wayne State University, Detroit Medical Center, Michigan.
Am J Clin Pathol. 1990 Sep;94(3):323-5. doi: 10.1093/ajcp/94.3.323.
Two hundred two slide latex agglutination (SLA) tests were performed on 137 women attending a vaginitis clinic to evaluate the efficacy of this new test in diagnosing acute symptomatic Candida vaginitis. In 77 patients with acute Candida vaginitis, the SLA test revealed a positive reaction in 56 patients, reflecting a sensitivity of 72.7%, lower than that observed with the 10% potassium hydroxide microscopic examination (sensitivity 90%). False negative SLA reactions could not be accounted for by lower numbers of yeast cultured from the vagina or by the presence of nonalbicans strains of Candida. Following successful antimycotic therapy, the SLA test promptly became negative in all mycologically negative patients. Application of the SLA test in asymptomatic healthy control women revealed extremely few false positive reactions for Candida (5.6%). This easily performed and rapid slide latex agglutination test should provide a useful adjunct to the diagnosis of Candida vaginitis, but only for physicians who do not routinely perform microscopy on vaginal secretions.
对137名前往阴道炎门诊就诊的女性进行了202次玻片乳胶凝集（SLA）试验，以评估这项新试验在诊断急性症状性念珠菌性阴道炎中的效果。在77例急性念珠菌性阴道炎患者中，SLA试验显示56例呈阳性反应，灵敏度为72.7%，低于10%氢氧化钾显微镜检查的灵敏度（90%）。SLA试验假阴性反应不能用从阴道培养出的酵母菌数量较少或存在非白色念珠菌菌株来解释。抗真菌治疗成功后，所有真菌学检查阴性的患者SLA试验迅速转为阴性。对无症状健康对照女性进行SLA试验，结果显示念珠菌假阳性反应极少（5.6%）。这项易于操作且快速的玻片乳胶凝集试验应为念珠菌性阴道炎的诊断提供有用的辅助手段，但仅适用于不常规对阴道分泌物进行显微镜检查的医生。
