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吸入性白细胞介素-10 可减轻失血性休克后的肺部炎症，而不会对全身炎症反应产生重大影响。

Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major alterations of the systemic inflammatory response.

机构信息

Department of Orthopaedic Trauma Surgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstraβe 30, 52074 Aachen, Germany.

出版信息

Mediators Inflamm. 2012;2012:512974. doi: 10.1155/2012/512974. Epub 2011 Oct 20.

DOI:10.1155/2012/512974
PMID:22046081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3199193/
Abstract

Several studies report immunomodulatory effects of endogenous IL-10 after trauma. The present study investigates the effect of inhalative IL-10 administration on systemic and pulmonary inflammation in hemorrhagic shock. Male C57/BL6 mice (8 animals per group) were subjected to pressure-controlled hemorrhagic shock for 1.5 hrs followed by resuscitation and inhalative administration of either 50 μL PBS (Shock group) or 50 μg/kg recombinant mouse IL-10 dissolved in 50 μL PBS (Shock + IL-10 group). Animals were sacrificed after 4.5 hrs of recovery and serum IL-6, IL-10, KC, and MCP-1 concentrations were measured with ELISA kits. Acute pulmonary inflammation was assessed by pulmonary myeloperoxidase (MPO) activity and pulmonary H&E histopathology. Inhalative IL-10 administration decreased pulmonary inflammation without altering the systemic concentrations of IL-6, IL-10, and KC. Serum MCP-1 levels were significantly reduced following inhalative IL-10 administration. These findings suggest that inhalative IL-10 administration may modulate the pulmonary microenvironment without major alterations of the systemic inflammatory response, thus minimizing the potential susceptibility to infection and sepsis.

摘要

几项研究报告创伤后内源性 IL-10 具有免疫调节作用。本研究探讨了吸入 IL-10 给药对失血性休克中全身和肺部炎症的影响。雄性 C57/BL6 小鼠（每组 8 只动物）接受压力控制的失血性休克 1.5 小时，然后进行复苏并吸入给予 50 μL PBS（休克组）或 50 μg/kg 重组小鼠 IL-10 溶解在 50 μL PBS 中（休克+IL-10 组）。恢复 4.5 小时后处死动物，并使用 ELISA 试剂盒测量血清 IL-6、IL-10、KC 和 MCP-1 浓度。通过肺髓过氧化物酶 (MPO) 活性和肺苏木精-伊红组织病理学评估急性肺炎症。吸入 IL-10 给药可减轻肺部炎症，而不改变全身 IL-6、IL-10 和 KC 的浓度。吸入 IL-10 给药后血清 MCP-1 水平显著降低。这些发现表明，吸入 IL-10 给药可能调节肺部微环境，而不会对全身炎症反应产生重大改变，从而最大程度地降低感染和败血症的潜在易感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/b4b98edb3031/MI2012-512974.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/3be4d4d40b65/MI2012-512974.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/e3a9d72cc6c4/MI2012-512974.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/b4b98edb3031/MI2012-512974.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/3be4d4d40b65/MI2012-512974.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/e3a9d72cc6c4/MI2012-512974.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445f/3199193/b4b98edb3031/MI2012-512974.003.jpg

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