Brüssow H, Sidoti J, Link H, Hoang Y K, Barclay D, Dirren H, Freire W B
Nestlé Research Center, Nestec, Lausanne, Switzerland.
J Infect Dis. 1990 Oct;162(4):974-7. doi: 10.1093/infdis/162.4.974.
Serum samples from 1397 Ecuadorian children 0-5 years of age were tested by ELISA for antibodies to enterotoxigenic Escherichia coli (ETEC). A gradual prevalence and titer increase was seen for IgG antibodies to heat-labile enterotoxin in children 6-18 months old; 90% prevalences were reached in the second year of life. At this age less than 10% of West German children showed IgG antibodies to heat-labile enterotoxin. In Ecuador age-related ETEC-specific antibody titer increases correlated with age-related prevalence of diarrheal disease. On the other hand, pooled lipopolysaccharide from different ETEC-associated O serogroups could not be used as a seroepidemiologic marker of ETEC infections.
采用酶联免疫吸附测定（ELISA）对1397名0至5岁厄瓜多尔儿童的血清样本进行了检测，以检测产肠毒素大肠杆菌（ETEC）抗体。6至18个月大的儿童中，对不耐热肠毒素的IgG抗体患病率和滴度逐渐上升；在生命的第二年达到了90%的患病率。在这个年龄段，不到10%的西德儿童显示出对不耐热肠毒素的IgG抗体。在厄瓜多尔，与年龄相关的ETEC特异性抗体滴度增加与腹泻病的年龄相关患病率相关。另一方面，来自不同ETEC相关O血清群的合并脂多糖不能用作ETEC感染的血清流行病学标志物。
