Roche P W, Britton W J, Failbus S S, Williams D, Pradhan H M, Theuvenet W J
Mycobacterial Research Laboratory, Anandaban Leprosy Hospital, Kathmandu, Nepal.
Int J Lepr Other Mycobact Dis. 1990 Sep;58(3):480-90.
The antibody responses of 100 previously untreated multibacillary (MB) leprosy patients to one protein and two carbohydrate antigens were examined: 94% of the patients had Mycobacterium leprae-specific antibodies; 89% directed to the species-specific epitope on phenolic glycolipid (PGL-I), 89% against the specific epitope on the 35-kDa protein, and 94% against one or both of the two. By contrast, 67% of the patients had anti-lipoarabinomannan (LAM) antibodies. There were trends for the seropositivity rate and the antibody level to rise with the increasing extent of the disease and as patients moved to the polar lepromatous end of the spectrum. The bacillary load, as measured by the bacterial index, was moderately correlated with the IgM anti-PGL-I and the anti-35-kDa antibody levels and, to a lesser extent, with the IgG antibodies directed at the common mycobacterial carbohydrate LAM. The sensitivity of the IgM anti-PGL-I antibodies for detecting smear-positive MB disease was 91%; that for the anti-35-kDa antibodies was 92%.
对100例未经治疗的多菌型（MB）麻风患者针对一种蛋白质抗原和两种碳水化合物抗原的抗体反应进行了检测：94%的患者有麻风分枝杆菌特异性抗体；89%针对酚糖脂（PGL-I）上的种特异性表位，89%针对35 kDa蛋白上的特异性表位，94%针对两者之一或两者。相比之下，67%的患者有抗脂阿拉伯甘露聚糖（LAM）抗体。血清阳性率和抗体水平有随着疾病程度增加以及患者向光谱的极型瘤型端转变而上升的趋势。通过细菌指数测量的菌负荷与IgM抗PGL-I和抗35 kDa抗体水平呈中度相关，在较小程度上与针对常见分枝杆菌碳水化合物LAM的IgG抗体相关。IgM抗PGL-I抗体检测涂片阳性MB病的敏感性为91%；抗35 kDa抗体的敏感性为92%。
