咖啡因对哮喘患者组胺支气管激发试验的影响。
Effect of caffeine on histamine bronchoprovocation in asthma.
作者信息
Colacone A, Bertolo L, Wolkove N, Cohen C, Kreisman H
机构信息
Department of Medicine, Sir Mortimer B Davis-Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Thorax. 1990 Aug;45(8):630-2. doi: 10.1136/thx.45.8.630.
It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.
最近有报道称，咖啡因可能会减轻哮喘的临床症状，并可能预防该疾病的临床表现。咖啡因对组胺反应性的影响尚不清楚。在10名轻度哮喘患者（激发前FEV1为预测值的84%）中，研究了咖啡因（5毫克/千克）和安慰剂对组胺反应性（导致FEV1下降20%的激发浓度，PC20）的影响。摄入咖啡因后组胺支气管激发试验的PC20为2.65（95%置信区间0.99，7.10）毫克/毫升。服用安慰剂后，PC20为1.89（0.96，3.71）毫克/毫升。得出的结论是，相当于约三杯咖啡剂量的咖啡因对轻度哮喘患者的组胺支气管激发试验影响极小（如果有影响的话）。因此，在组胺激发试验前没有必要特别说明不要饮用含咖啡因的饮料。
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