State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China;
Invest Ophthalmol Vis Sci. 2011 Dec 9;52(13):9404-10. doi: 10.1167/iovs.11-8470.
To assess the anterior chamber drainage angle width in the dark and the dark-to-light change (Δ) between Caucasians and Chinese aged 40 years and older.
The study groups comprised four age- and sex-matched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. Anterior segment optical coherence tomography (ASOCT) images of the anterior chamber angles were obtained under both light and dark conditions. The parameters analyzed included angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA).
Data were obtained from 121, 124, 121, and 120 participants who were American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. In a multiple linear regression analysis, adjusted for age, sex, refractive status, pupil size, lens location, and anterior chamber depth (ACD) and width (ACW), the ethnic Chinese had significantly smaller ARAs (regression coefficient, β = -0.06, P < 0.001) and TISAs (β = -0.01, P = 0.039), as well as greater ΔAODs (β = 0.03, P = 0.009) and ΔTISAs (β = 0.02, P = 0.029) than did the Caucasians. For the dark-to-light change analysis, the independent associations between angle width and iris thickness (IT) and iris curvature (ICurv) were identified only in the Chinese.
Compared with the Caucasians, the ethnic Chinese had smaller ARA and TISA, but greater dark-to-light changes in AOD and TISA, independent of refractive status and overall ocular anterior segment dimensions.
评估白种人和 40 岁及以上的中国人群在暗光和暗光-亮光变化（Δ）下的前房排水角度宽度。
研究组包括四个年龄和性别匹配的队列：美国白种人、美国华人、中国南方人和中国北方人。在暗光和亮光条件下，使用眼前节光学相干断层扫描（ASOCT）获取前房角图像。分析的参数包括房角开口距离（AOD）、房角隐窝面积（ARA）和小梁虹膜空间面积（TISA）。
数据来自分别为 121、124、121 和 120 名美国白种人、美国华人、中国南方人和中国北方人的参与者。在一项多元线性回归分析中，调整了年龄、性别、屈光状态、瞳孔大小、晶状体位置、前房深度（ACD）和宽度（ACW），华裔人群的 ARA 明显较小（回归系数，β=-0.06，P<0.001）和 TISA（β=-0.01，P=0.039），以及更大的 ΔAOD（β=0.03，P=0.009）和 ΔTISA（β=0.02，P=0.029）。对于暗光-亮光变化分析，只有在中国人中才确定了角度宽度与虹膜厚度（IT）和虹膜曲率（ICurv）之间的独立关联。
与白种人相比，中国人群的 ARA 和 TISA 较小，但 AOD 和 TISA 的暗光-亮光变化较大，与屈光状态和整个眼前段尺寸无关。
