Easterbrook M
Department of Ophthalmology, University of Toronto, Ont.
Can J Ophthalmol. 1990 Aug;25(5):249-51.
Ninety-five percent of patients on chloroquine demonstrate corneal deposition of the drug with the pupil dilated; less than 10% of patients on hydroxychloroquine show any corneal changes when so examined. I describe one patient on chloroquine and two on hydroxychloroquine who demonstrated large amounts of corneal antimalarial drug, leading to the early diagnosis of definite retinopathy. Examination of the cornea with the pupil dilated may reveal the presence of retinal toxicity in some patients.
服用氯喹的患者中有95%在瞳孔散大时出现药物在角膜的沉积；而接受羟氯喹治疗的患者在进行此项检查时，出现角膜改变的比例不到10%。我描述了1例服用氯喹和2例服用羟氯喹的患者，他们角膜上出现了大量抗疟药物沉积，从而得以早期确诊明确的视网膜病变。在瞳孔散大状态下检查角膜，可能会发现部分患者存在视网膜毒性。
