人类甲状腺组织中的性激素受体。

Sex hormone receptors in human thyroid tissues.

作者信息

Miki H, Oshimo K, Inoue H, Morimoto T, Monden Y

机构信息

Second Department of Surgery, School of Medicine, University of Tokushima, Japan.

出版信息

Cancer. 1990 Oct 15;66(8):1759-62. doi: 10.1002/1097-0142(19901015)66:8<1759::aid-cncr2820660820>3.0.co;2-x.

DOI:10.1002/1097-0142(19901015)66:8<1759::aid-cncr2820660820>3.0.co;2-x

PMID:2208032

Abstract

The behavior of sex hormone receptors was studied in the cytosol of thyroid tissue samples in order to clarify the effects of sex hormones on diseases of the thyroid. Androgen receptor (AR), estrogen receptor (ER), and progesterone receptor (PgR) were assayed using the dextran-coated charcoal (DCC) method and analyzed by the method of Scatchard. Androgen receptor, ER, and PgR were negative in all of the cytosol prepared from normal thyroid tissues. However, the positive rates for the receptors in the neoplastic and nonneoplastic tissues were 22% for AR, 29% for ER, and 18% for PgR. Especially, the incidence of ER was significantly higher in neoplastic lesions than normal tissues. These data suggest that sex hormones, especially estrogen, may play a role in diseases of the thyroid.

摘要

为了阐明性激素对甲状腺疾病的影响，对甲状腺组织样本的胞质溶胶中性激素受体的行为进行了研究。采用葡聚糖包被活性炭（DCC）法检测雄激素受体（AR）、雌激素受体（ER）和孕激素受体（PgR），并用Scatchard法进行分析。在所有由正常甲状腺组织制备的胞质溶胶中，雄激素受体、ER和PgR均为阴性。然而，肿瘤组织和非肿瘤组织中受体的阳性率分别为：AR为22%，ER为29%，PgR为18%。特别是，ER在肿瘤病变中的发生率明显高于正常组织。这些数据表明，性激素，尤其是雌激素，可能在甲状腺疾病中起作用。