树突 SNARE 为古老的神经元理论增添了新意。
Dendritic SNAREs add a new twist to the old neuron theory.
机构信息
International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland.
出版信息
Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19113-20. doi: 10.1073/pnas.1017235108. Epub 2011 Nov 11.
Abstract
Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.
摘要
树突胞吐作用为基础的广泛的整合和自稳态突触功能。新兴的数据强调 SNAREs 在运输和融合的分泌细胞器与肽和神经递质从树突释放的重要作用。这个观点分析了最近的证据推断轴树突极化囊泡释放机制，并指出在这个快速发展的领域的树突研究进展的挑战。解释新的分子数据与生理结果之间的关系从树突分泌将极大地促进我们对神经元机制的这一方面的理解。
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