Xie Wen, Denman Robert B
Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 1065, USA.
Mol Biol Int. 2011;2011:137459. doi: 10.4061/2011/137459. Epub 2011 Feb 24.
Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types.
应激颗粒包含大量经翻译后修饰的蛋白质，研究表明这些修饰作为特定蛋白质的招募标签，甚至控制颗粒自身的组装与解体。我们实验室开展的工作聚焦于蛋白质甲基化在应激颗粒组成和功能中所起的作用。我们已经证明，不对称和对称二甲基化的蛋白质都是应激颗粒的核心成分，并且我们一直在努力了解这种情况何时以及如何发生。在此，我们试图将这些数据整合到一个由目前已知的影响应激颗粒的翻译后修饰组成的框架中，以构建一个应激颗粒动力学模型，进而可作为理解和预测翻译后修饰如何调控其他颗粒类型的基准。
