Dental School, University of Chieti-Pescara, Chieti, Italy.
Clin Oral Implants Res. 2012 Dec;23(12):1369-76. doi: 10.1111/j.1600-0501.2011.02308.x. Epub 2011 Nov 2.
Various grafts or combination of graft materials have been used in sinus floor augmentations, and human histological reports on their performance are available, although limited in number. Histological analysis of the regenerated tissues will provide useful information regarding the nature and amount of newly formed bone. Aim of the present study was a histological and histomorphometric evaluation, in humans, of specimens retrieved from sinuses augmented with phycogene hydroxyapatite, biphasic calcium phosphate ceramics, calcium carbonate, porcine bone and anorganic bovine bone, after a healing period of 6 months.
A total of 15 patients, undergoing 30 sinus augmentation procedures with five different biomaterials, participated in this study. A total of 82 titanium dental implants were inserted in the augmented sinuses after a healing period of 6 months. A total of 60 bone cores, 2 for each augmented sinus, 12 for every biomaterial, were retrieved and all were stored immediately in 10% buffered formalin and processed to obtain thin ground sections.
In all biomaterials, many grafted particles were lined and, sometimes, bridged by newly formed bone. Some biomaterials particles appeared to be partially resorbed and substituted by newly formed bone. Histomorphometry showed that, in all biomaterials, newly formed bone and residual grafted material particles represented about 30%.
Longer term histological and histomorphometric studies will be necessary to understand better the resorption times of all these biomaterials. The high interconnecting microporosity allowed, in all the present biomaterials, the ingrowth of newly formed bone and vessels in the pores of the partially resorbed particles. In conclusion, within the limitations of the present study, the data provided support the fact that all these biomaterials can be used, successfully, in sinus augmentation procedures.
各种移植物或移植物材料的组合已被用于鼻窦底提升术，并且有关于其性能的人体组织学报告，尽管数量有限。对再生组织的组织学分析将提供有关新形成骨的性质和数量的有用信息。本研究的目的是对用藻酸钙羟基磷灰石、双相磷酸钙陶瓷、碳酸钙、猪骨和无机牛骨增强的鼻窦中取出的标本进行组织学和组织形态计量学评估，这些标本在 6 个月的愈合期后进行了评估。
共有 15 名患者参与了这项研究，他们接受了 30 例不同生物材料的鼻窦增强手术。在 6 个月的愈合期后，共在增强的鼻窦中植入了 82 个钛牙种植体。总共取出了 60 个骨芯，每个增强的鼻窦 2 个，每个生物材料 12 个，所有骨芯都立即储存在 10%缓冲福尔马林中，并进行处理以获得薄的磨片。
在所有生物材料中，许多移植颗粒被新形成的骨覆盖和有时桥接。一些生物材料颗粒似乎部分被吸收并被新形成的骨取代。组织形态计量学显示，在所有生物材料中，新形成的骨和残留的移植颗粒材料约占 30%。
需要进行更长时间的组织学和组织形态计量学研究，以更好地了解所有这些生物材料的吸收时间。高连通的微孔允许在所有目前的生物材料中，新形成的骨和血管在部分吸收颗粒的孔中生长。总之，在本研究的限制范围内，所提供的数据支持以下事实，即所有这些生物材料都可以成功地用于鼻窦提升术。
