Department of Neurology, University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St., Philadelphia, PA 19104, USA.
Neurology. 2011 Nov 29;77(22):1977-85. doi: 10.1212/WNL.0b013e31823a0ef7. Epub 2011 Nov 16.
We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls.
Fifteen patients with AD (mean age 72 ± 6 years, Mini-Mental State Examination score [MMSE] 20 ± 6) and 19 age-matched controls (mean age 68 ± 6 years, MMSE 29 ± 1) underwent structural MRI. Participants were injected with 5 mCi of FDG during pseudocontinuous ASL scan, which was followed by PET scanning. Statistical parametric mapping and regions of interest (ROI) analysis were used to compare the ability of the 2 modalities in distinguishing patients from controls. Similarity between the 2 modalities was further assessed with linear correlation maps of CBF and metabolism to neuropsychological test scores.
Good agreement between hypoperfusion and hypometabolism patterns was observed, with overlap primarily in bilateral angular gyri and posterior cingulate. ROI results showed similar scales of functional deficit between patients and controls in both modalities. Both ASL and FDG-PET were able to distinguish neural networks associated with different neuropsychological tests with good overlap between modalities.
Our voxel-wise results indicated that ASL-MRI provides largely overlapping information with FDG-PET. ROI analysis demonstrated that both modalities detected similar degrees of functional deficits in affected areas. Given its ease of acquisition and noninvasiveness, ASL-MRI may be an appealing alternative for AD studies.
我们比较了动脉自旋标记（ASL）——一种测量脑血流（CBF）的 MRI 方法，与 FDG-PET 在区分阿尔茨海默病（AD）患者与健康、年龄匹配的对照组方面的能力。
15 例 AD 患者（平均年龄 72 ± 6 岁，简易精神状态检查量表[MMSE]评分 20 ± 6）和 19 名年龄匹配的对照组（平均年龄 68 ± 6 岁，MMSE 评分 29 ± 1）接受了结构 MRI 检查。参与者在伪连续 ASL 扫描期间注射 5mCi 的 FDG，随后进行 PET 扫描。统计参数映射和感兴趣区域（ROI）分析用于比较两种模式区分患者与对照组的能力。还通过 CBF 和代谢与神经心理学测试评分的线性相关图进一步评估两种模式之间的相似性。
观察到灌注不足和代谢低下模式之间存在良好的一致性，主要重叠于双侧角回和后扣带回。ROI 结果表明，两种模式在患者和对照组之间的功能缺陷程度相似。ASL 和 FDG-PET 都能够区分与不同神经心理学测试相关的神经网络，两种模式之间存在良好的重叠。
我们的体素水平结果表明，ASL-MRI 提供了与 FDG-PET 基本重叠的信息。ROI 分析表明，两种模式都在受影响区域检测到了相似程度的功能缺陷。鉴于其易于采集和非侵入性，ASL-MRI 可能是 AD 研究的一种有吸引力的替代方法。
