Gunel T, Zeybek Y G, Akçakaya P, Kalelioğlu I, Benian A, Ermis H, Aydınlı K
Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
Genet Mol Res. 2011 Nov 8;10(4):4034-40. doi: 10.4238/2011.November.8.5.
Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients.We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
子痫前期仍然是全球孕妇的一种致命疾病。最近，遗传学家与产科医生合作，开辟了新的领域。微小RNA（miRNA）是一类小的非编码RNA分子成员。它们是基因表达的关键转录后调节因子。我们从母体血浆中提取循环miRNA，并对mir-152和mir-210进行定量。我们发现子痫前期患者中miR-210水平上调以及mir-152水平下调。我们提出，检测母体血清中mir-210水平升高可用于改进子痫前期非侵入性产前诊断的预测方法。
