抗体在癌症靶向治疗中的作用。
Role of antibodies in cancer targeting.
作者信息
Attarwala Husain
机构信息
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, USA.
出版信息
J Nat Sci Biol Med. 2010 Jul;1(1):53-6. doi: 10.4103/0976-9668.71675.
Abstract
The development of chemotherapeutic agents capable of specifically eliminating tumor cells has been a great challenge since these agents cannot differentiate between normal body cells and tumor cells. Enhanced elimination of cancer cells without affecting normal body cells can be achieved by developing strategies which can enable drug targeting. With recent advances in antibody engineering strategies, the development of different antibody-associated tumor-targeted delivery systems for chemotherapy, chemoprevention, and early cancer diagnosis has become possible. In this review, the role of antibodies for cancer diagnosis, chemoprevention, and chemotherapy will be discussed with an emphasis on recent advances in antibody engineering.
摘要
由于化疗药物无法区分正常体细胞和肿瘤细胞，因此开发能够特异性消除肿瘤细胞的化疗药物一直是一项巨大的挑战。通过开发能够实现药物靶向的策略，可以在不影响正常体细胞的情况下增强癌细胞的消除。随着抗体工程策略的最新进展，开发用于化疗、化学预防和早期癌症诊断的不同抗体相关肿瘤靶向递送系统已成为可能。在这篇综述中，将讨论抗体在癌症诊断、化学预防和化疗中的作用，并重点介绍抗体工程的最新进展。
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