Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, SE-118 83 Stockholm, Sweden.
Br J Dermatol. 2012 Apr;166(4):879-83. doi: 10.1111/j.1365-2133.2011.10747.x. Epub 2012 Mar 2.
Previous studies have shown different bacteria in hidradenitis suppurativa (HS) lesions, but the literature regarding bacteria in acute exacerbation of HS is sparse.
To determine the type of bacteria isolated from HS lesions during exacerbations of the disease.
Patients with HS with acute nodules or abscesses were examined and treated by carbon dioxide laser vaporization. Bacterial samples for aerobic and anaerobic cultures were taken from the skin surface (before surgery) and then from the deeper layers (during surgery) of the lesions. At each level two samples were taken, one with a punch biopsy and one by pressing a soft agar gel against the skin. The bacterial findings were typed and quantified.
A total of 10 patients (eight women and two men), with a mean age of 37·2 years and a mean HS duration of 14·5 years, were included. All of them had an ongoing exacerbation (mean duration 5·6 days) of their HS, with one inflamed lesion that was treated by carbon dioxide laser vaporization. Coagulase-negative staphylococci (CNS) were found in the deep layers in all 10 patients. Nine of the patients carried Corynebacterium spp. and two alpha-haemolytic streptococci at various levels. Among the anaerobic microorganisms, Gram-positive cocci were the most common bacteria.
As found in a previous study, CNS were the most common bacteria, but contrary to what we expected, Staphylococcus aureus was not found in any cultures from acute inflammatory nodules of HS exacerbations.
先前的研究表明，化脓性汗腺炎（HS）病变中存在不同的细菌，但关于 HS 急性加重期细菌的文献却很少。
确定在疾病急性加重期从 HS 病变中分离出的细菌类型。
对患有急性结节或脓肿的 HS 患者进行检查并采用二氧化碳激光汽化进行治疗。从病变的皮肤表面（手术前）和深层（手术时）采集需进行需氧和厌氧培养的细菌样本。在每个层面采集两个样本，一个采用打孔活检，另一个将软琼脂凝胶压在皮肤上。对细菌发现进行分型和定量。
共纳入 10 例（8 名女性和 2 名男性）患者，平均年龄 37.2 岁，HS 病程平均为 14.5 年。他们均处于 HS 的持续加重期（平均持续时间 5.6 天），有一个炎症性病变接受了二氧化碳激光汽化治疗。在所有 10 例患者的深层均发现凝固酶阴性葡萄球菌（CNS）。9 例患者在不同层面携带棒状杆菌属和 2 例甲型溶血性链球菌。在厌氧微生物中，革兰阳性球菌是最常见的细菌。
与先前的研究一致，CNS 是最常见的细菌，但与我们预期的相反，在 HS 急性炎症性结节的任何培养物中均未发现金黄色葡萄球菌。
