Division of Viral Infections, Robert Koch-Institut, Nordufer 20, D-13353 Berlin, Germany.
Virus Res. 2012 Mar;164(1-2):54-60. doi: 10.1016/j.virusres.2011.11.001. Epub 2011 Nov 9.
This review discusses the molecular interaction of proteins encoded by porcine circoviruses type 1 (PCV1) and type 2 (PCV2) with respect to the putative role for disease induction. Besides protein:protein interactions also proteins binding to PCV DNA are covered. Moreover, new approaches are considered which have been generated by genomic and proteomic techniques. PCV are still an enigma, when communication with the host and induction of disease are concerned. This is remarkably, since comparison of two viruses with a size of less than 2000 nts should easily identify the molecular trigger responsible for pathogenicity of PCV2. Since scientific life isn't all beer and skittles we have to accept that this conundrum may be solved only in a long time range. The good news is that some common themes become visible and that certain aspects of the cell life cycle have been identified to be involved in interaction with the pathogen.
这篇综述讨论了猪圆环病毒 1 型（PCV1）和 2 型（PCV2）编码的蛋白质的分子相互作用，以及它们在疾病诱导中的可能作用。除了蛋白质-蛋白质相互作用外，还涵盖了与 PCV DNA 结合的蛋白质。此外，还考虑了通过基因组和蛋白质组技术产生的新方法。当涉及到与宿主的通讯和疾病的诱导时，PCV 仍然是一个谜。这很明显，因为比较两个大小不到 2000 个核苷酸的病毒应该很容易确定导致 PCV2 致病性的分子触发因素。由于科学生活并不全是轻松愉快的，我们必须接受这个难题可能需要很长时间才能解决。好消息是，一些共同的主题变得明显，并且某些细胞生命周期的方面已被确定与病原体的相互作用有关。
