Lv Qi-Zhuang, Guo Kang-Kang, Zhang Yan-Ming
College of Veterinary Medicine, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Virus Genes. 2014 Aug;49(1):1-10. doi: 10.1007/s11262-014-1099-z. Epub 2014 Jul 11.
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases in swine and is also described as the modulator of host immunity that exacerbates the clinical outcome of many bacterial and viral infections. To date, it has caused increasingly larger losses in the pig industry worldwide. The genomic DNA of PCV2 is predicted to contain 11 open reading frames (ORFs) and at least seven potential ORFs-encoding proteins larger than 5 kDa. Currently, however, only five virally encoded proteins (Rep, Rep', Cap, ORF3, and ORF4 protein) have been identified in PCV2 replication. In the present review, we strive to discuss the current understanding of the genomic DNA of PCV2 with the purpose of providing insight into the scientific basis of the pathogenesis of PCV2 and the prevention of its infection.
猪圆环病毒2型（PCV2）是猪圆环病毒相关疾病的主要病原体，也被描述为宿主免疫调节剂，它会加剧许多细菌和病毒感染的临床后果。迄今为止，它已在全球养猪业中造成越来越大的损失。PCV2的基因组DNA预计包含11个开放阅读框（ORF）和至少7个潜在的编码大于5 kDa蛋白质的ORF。然而，目前在PCV2复制过程中仅鉴定出5种病毒编码蛋白（Rep、Rep'、Cap、ORF3和ORF4蛋白）。在本综述中，我们力求讨论对PCV2基因组DNA的当前认识，旨在深入了解PCV2发病机制的科学基础及其感染的预防。
