Das Samarjit, Steenbergen Charles, Murphy Elizabeth
Department of Pathology, Johns Hopkins Medical Institute and Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA.
Biochim Biophys Acta. 2012 Jun;1818(6):1451-6. doi: 10.1016/j.bbamem.2011.11.008. Epub 2011 Nov 11.
The voltage dependent anion channel (VDAC) provides exchange of metabolites, anions, and cations across the outer mitochondrial membrane. VDAC provides substrates and adenine nucleotides necessary for electron transport and therefore plays a key role in regulating mitochondrial bioenergetics. VDAC has also been suggested to regulate the response to cell death signaling. Emerging data show that VDAC is regulated by protein-protein interactions as well as by post-translational modifications. This review will focus on the regulation of VDAC and its potential role in regulating cell death in cardiac ischemia-reperfusion. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism.
电压依赖性阴离子通道（VDAC）介导代谢物、阴离子和阳离子在线粒体外膜上的交换。VDAC为电子传递提供必要的底物和腺嘌呤核苷酸，因此在调节线粒体生物能量学中起关键作用。VDAC也被认为参与调节细胞对死亡信号的反应。新出现的数据表明，VDAC受蛋白质-蛋白质相互作用以及翻译后修饰的调控。本综述将聚焦于VDAC的调控及其在心脏缺血再灌注中调节细胞死亡的潜在作用。本文是名为“VDAC的结构、功能及线粒体代谢调控”的特刊的一部分。
