Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Schizophr Bull. 2012 Mar;38(2):239-46. doi: 10.1093/schbul/sbr164. Epub 2011 Nov 17.
While a great deal of research has been conducted on prodromal risk syndromes in relation to help-seeking individuals who present to the clinic, there is a lack of research on prodromal risk syndromes in the general population. The current study aimed first to establish whether prodromal risk syndromes could be detected in non-help-seeking community-based adolescents and secondly to characterize this group in terms of Axis-1 psychopathology and general functioning. We conducted in-depth clinical interviews with a population sample of 212 school-going adolescents in order to assess for prodromal risk syndromes, Axis-1 psychopathology, and global (social/occupational) functioning. Between 0.9% and 8% of the community sample met criteria for a risk syndrome, depending on varying disability criteria. The risk syndrome group had a higher prevalence of co-occurring nonpsychotic Axis-1 psychiatric disorders (OR = 4.77, 95% CI = 1.81-12.52; P < .01) and poorer global functioning (F = 24.5, df = 1, P < .0001) compared with controls. Individuals in the community who fulfill criteria for prodromal risk syndromes demonstrate strong similarities with clinically presenting risk syndrome patients not just in terms of psychotic symptom criteria but also in terms of co-occurring psychopathology and global functioning.
虽然已经有大量研究针对寻求专业帮助的个体出现的前驱风险综合征进行了研究，但针对普通人群中的前驱风险综合征的研究却相对较少。本研究旨在首先确定前驱风险综合征是否可以在非寻求专业帮助的社区青少年中被检测到，其次是根据轴一精神病理学和一般功能来描述这一群体。我们对 212 名在校青少年进行了深入的临床访谈，以评估前驱风险综合征、轴一精神病理学和整体（社交/职业）功能。根据不同的残疾标准，社区样本中有 0.9%至 8%的人符合风险综合征的标准。风险综合征组有更高的共患非精神病性轴一精神障碍的患病率（OR = 4.77，95% CI = 1.81-12.52；P <.01）和较差的整体功能（F = 24.5，df = 1，P <.0001）与对照组相比。在社区中符合前驱风险综合征标准的个体，不仅在精神病症状标准方面，而且在共患精神病理学和整体功能方面，与临床出现风险综合征的患者有很强的相似性。
