Crabtree J E, Juby L D, Heatley R V, Lobo A J, Bullimore D W, Axon A T
Department of Medicine, St James's University Hospital, Leeds.
Gut. 1990 Sep;31(9):1033-6. doi: 10.1136/gut.31.9.1033.
Serum concentrations of soluble interleukin-2 receptor (sIL-2R) were measured as a marker of immune activation in a group of 30 patients with Crohn's disease. sIL-2R concentrations were determined by enzyme linked immunosorbent assay during periods of active and inactive disease and correlated with standard parameters of disease activity. Serum concentrations of sIL-2R were significantly raised in patients with active Crohn's disease compared with patients with inactive disease (p less than 0.001) and control subjects. There was a significant correlation between serum sIL-2R concentrations and disease activity as assessed by the Harvey-Bradshaw index (r = 0.42, p less than 0.01), platelet numbers (r = 0.49, p less than 0.01), and orosomucoid (r = 0.47, p less than 0.01), alpha 1 antitrypsin (r = 0.44, p less than 0.01), and C reactive protein concentrations (r = 0.48, p less than 0.001) but not with the erythrocyte sedimentation rate. Measurement of serum sIL-2R concentration is a simple and useful laboratory means of assessing disease activity. Raised concentrations in patients with active Crohn's disease is further evidence for in vivo immune activation occurring in this disease.
对一组30例克罗恩病患者测定血清可溶性白细胞介素-2受体（sIL-2R）浓度，作为免疫激活的标志物。在疾病活动期和非活动期通过酶联免疫吸附测定法测定sIL-2R浓度，并将其与疾病活动的标准参数相关联。与非活动期患者及对照受试者相比，活动期克罗恩病患者的血清sIL-2R浓度显著升高（p<0.001）。血清sIL-2R浓度与通过哈维-布拉德肖指数评估的疾病活动度（r = 0.42，p<0.01）、血小板数量（r = 0.49，p<0.01）以及血清类黏蛋白（r = 0.47，p<0.01）、α1抗胰蛋白酶（r = 0.44，p<0.01）和C反应蛋白浓度（r = 0.48，p<0.001）之间存在显著相关性，但与红细胞沉降率无关。测定血清sIL-2R浓度是评估疾病活动度的一种简单且有用的实验室方法。活动期克罗恩病患者sIL-2R浓度升高是该疾病体内发生免疫激活的进一步证据。
