十二指肠溃疡与膳食中亚油酸摄入量低有关。
Duodenal ulcer is associated with low dietary linoleic acid intake.
作者信息
Grant H W, Palmer K R, Riermesma R R, Oliver M F
机构信息
Gastrointestinal Unit, Western General Hospital, Edinburgh.
出版信息
Gut. 1990 Sep;31(9):997-8. doi: 10.1136/gut.31.9.997.
Abstract
It has been suggested that the falling incidence and virulence of duodenal ulcer is related to increased dietary polyunsaturated essential fatty acid intake. The adipose fatty acid profile, which closely reflects dietary intake, was measured in 35 men with chronic duodenal ulcer and 35 matched control men. The mean percentage of linoleic acid in adipose tissue was significantly lower in the ulcer group (10.0 (0.7) v 12.3 (0.7)%, p less than 0.01) and this difference was found in both smokers and non-smokers. This finding suggests that the diets of duodenal ulcer patients are deficient in linoleic acid and this could be of aetiological importance.
摘要
有人提出，十二指肠溃疡发病率和毒力的下降与膳食中多不饱和必需脂肪酸摄入量的增加有关。对35名患有慢性十二指肠溃疡的男性和35名匹配的对照男性测量了能密切反映膳食摄入情况的脂肪脂肪酸谱。溃疡组脂肪组织中亚油酸的平均百分比显著较低（10.0（0.7）%对12.3（0.7）%，p<0.01），且在吸烟者和非吸烟者中均发现了这种差异。这一发现表明，十二指肠溃疡患者的饮食中缺乏亚油酸，这可能具有病因学意义。
相似文献
1
Duodenal ulcer is associated with low dietary linoleic acid intake.
Gut. 1990 Sep;31(9):997-8. doi: 10.1136/gut.31.9.997.
2
Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease.
Am J Clin Nutr. 1993 Jan;57(1):70-2. doi: 10.1093/ajcn/57.1.70.
3
Biological markers of dietary intake, with emphasis on fatty acids.
Ann Nutr Metab. 1991;35(5):249-52. doi: 10.1159/000177653.
4
Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids.
Am J Clin Nutr. 2003 Apr;77(4):796-802. doi: 10.1093/ajcn/77.4.796.
5
Linoleic acid and risk of sudden cardiac death.
Br Heart J. 1993 Dec;70(6):524-9. doi: 10.1136/hrt.70.6.524.
6
Association of Adipose Tissue Fatty Acids With Cardiovascular and All-Cause Mortality in Elderly Men.
JAMA Cardiol. 2016 Oct 1;1(7):745-753. doi: 10.1001/jamacardio.2016.2259.
7
Cigarette smoking, polyunsaturated fats, linoleic acid, and coronary heart disease.
Lancet. 1989 Jun 3;1(8649):1241-3. doi: 10.1016/s0140-6736(89)92338-6.
8
Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats.
Br J Nutr. 2010 Mar;103(6):869-78. doi: 10.1017/S000711450999256X. Epub 2009 Nov 2.
9
Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice.
Obes Res. 2004 Sep;12(9):1435-44. doi: 10.1038/oby.2004.180.
10
Increase in adipose tissue linoleic acid of US adults in the last half century.
Adv Nutr. 2015 Nov 13;6(6):660-4. doi: 10.3945/an.115.009944. Print 2015 Nov.
引用本文的文献
1
Role of dietary phospholipids and phytosterols in protection against peptic ulceration as shown by experiments on rats.
World J Gastroenterol. 2015 Feb 7;21(5):1377-84. doi: 10.3748/wjg.v21.i5.1377.
2
Antiulcer activity of cod liver oil in rats.
Indian J Pharmacol. 2008 Oct;40(5):209-14. doi: 10.4103/0253-7613.44152.
3
Fatty acid composition of subcutaneous adipose tissue and gastric mucosa: is there a relation with gastric ulceration?
BMC Gastroenterol. 2009 Jan 23;9:9. doi: 10.1186/1471-230X-9-9.
4
How diet and lifestyle affect duodenal ulcers. Review of the evidence.
Can Fam Physician. 2004 May;50:727-32.
5
Helicobacter pylori: the primary cause of duodenal ulceration or a secondary infection?
World J Gastroenterol. 2001 Apr;7(2):149-51. doi: 10.3748/wjg.v7.i2.149.
6
Influence of dietary fat on duodenal resistance to acid.
Gut. 1993 Oct;34(10):1303-9. doi: 10.1136/gut.34.10.1303.
7
Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration.
Gut. 1994 Nov;35(11):1557-61. doi: 10.1136/gut.35.11.1557.
8
Dietary factors associated with duodenal ulcer.
Gut. 1991 Apr;32(4):456. doi: 10.1136/gut.32.4.456.
本文引用的文献
1
Arachidonic acid protection of rat gastric mucosa against ethanol injury.
J Lab Clin Med. 1982 Aug;100(2):296-308.
2
20 years of hospital admissions for peptic ulcer in England and Wales.
Lancet. 1981 Jun 13;1(8233):1302-4. doi: 10.1016/s0140-6736(81)92470-3.
3
Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man.
Life Sci. 1974 Feb 1;14(3):533-8. doi: 10.1016/0024-3205(74)90367-1.
4
Dietary essential fatty acids and the decline in peptic ulcer disease--a hypothesis.
Gut. 1986 Mar;27(3):239-42. doi: 10.1136/gut.27.3.239.
5
Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage.
Gastroenterology. 1988 Jul;95(1):18-25. doi: 10.1016/0016-5085(88)90285-5.
6
Dietary linoleic acid, gastric acid, and prostaglandin secretion.
Gastroenterology. 1988 Apr;94(4):955-9. doi: 10.1016/0016-5085(88)90553-7.
7
Linoleic and eicosapentaenoic acids in adipose tissue and platelets and risk of coronary heart disease.
Lancet. 1987 Jan 24;1(8526):177-83. doi: 10.1016/s0140-6736(87)90001-8.
8
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
Gastroenterology. 1979 Sep;77(3):433-43.
Zotero 插件