Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Ocul Immunol Inflamm. 2011 Dec;19(6):426-30. doi: 10.3109/09273948.2011.624287.
To measure the incidence of white dot syndromes (WDS) in a community-based population and to report clinical features and outcomes.
Multicenter retrospective study using the Rochester Epidemiology Project medical records linkage system of Olmsted County, Minnesota. Databases were searched to identify all patients with WDS from January 1, 1988 through December 31, 2008.
Mean ophthalmic follow-up was 4.5 years and mean general medical follow-up was 9.1 years. The incidence of WDS was 0.45 per 100,000 per year (95% CI 0.19-0.71). Incidence rates for specific disease entities were also calculated. The authors report some associated autoimmune diseases in this series. Multiple evanescent white dot syndrome (MEWDS) was more common in females, and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) was more common in males. Both MEWDS and APMPPE generally carried a good visual prognosis. Fifty percent of cases with APMPPE had a positive history of psoriasis. The only punctuate inner choroidopathy (PIC) case carried that diagnosis as well.
WDS are rare diseases and may be associated with other autoimmune diseases. Further studies with more patients and longer follow-up periods are needed to draw conclusions about visual prognosis, development of other ocular conditions, and associated medical diseases.
以社区人群为基础，测量白点综合征（WDS）的发病率，并报告其临床特征和结局。
采用明尼苏达州罗切斯特市罗切斯特流行病学项目病历链接系统的多中心回顾性研究。检索数据库，以确定 1988 年 1 月 1 日至 2008 年 12 月 31 日期间所有患有 WDS 的患者。
平均眼科随访时间为 4.5 年，平均一般医疗随访时间为 9.1 年。WDS 的发病率为每年每 10 万人 0.45 例（95%CI0.19-0.71）。还计算了特定疾病实体的发病率。本系列报告了一些相关的自身免疫性疾病。多发性一过性白点综合征（MEWDS）在女性中更为常见，急性后极多发性斑状色素上皮病变（APMPPE）在男性中更为常见。MEWDS 和 APMPPE 通常均具有良好的视力预后。50%的 APMPPE 病例有银屑病阳性病史。唯一的点状内层脉络膜病变（PIC）病例也有该诊断。
WDS 是罕见疾病，可能与其他自身免疫性疾病有关。需要进一步研究更多的患者和更长的随访时间，以得出关于视力预后、其他眼部疾病发展和相关内科疾病的结论。
