Dotevall L, Fuchs D, Reibnegger G, Wachter H, Hagberg L
Department of Infectious Diseases, University of Göteborg, Sweden.
Infection. 1990 Jul-Aug;18(4):210-4. doi: 10.1007/BF01643387.
Elevated (greater than 3.0 nmol/l) cerebrospinal fluid neopterin concentrations were observed in 20 of 21 patients with Lyme neuroborreliosis compared with three of 11 control patients with headache, back pain or psychoneurotic disorders. Neopterin concentrations were correlated to mononuclear cell counts and protein concentrations in the cerebrospinal fluid (CSF). Following antibiotic treatment, CSF neopterin levels decreased. Serum neopterin levels were not significantly raised in patients with neuroborreliosis when compared to control subjects. Neopterin levels as well as cell count and protein concentration in the CSF are valuable inflammation markers of disease activity in Lyme neuroborreliosis.
21例莱姆病神经疏螺旋体病患者中，有20例脑脊液新蝶呤浓度升高（大于3.0 nmol/l），相比之下，11例患有头痛、背痛或精神神经症的对照患者中有3例脑脊液新蝶呤浓度升高。新蝶呤浓度与脑脊液中的单核细胞计数及蛋白浓度相关。抗生素治疗后，脑脊液新蝶呤水平下降。与对照受试者相比，神经疏螺旋体病患者的血清新蝶呤水平没有显著升高。脑脊液中的新蝶呤水平以及细胞计数和蛋白浓度是莱姆病神经疏螺旋体病疾病活动的重要炎症标志物。
