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急性肺血栓栓塞症肺血栓切除术的结局:来自日本多中心注册研究的32例患者分析

Outcome of pulmonary embolectomy for acute pulmonary thromboembolism: analysis of 32 patients from a multicentre registry in Japan.

作者信息

Taniguchi Satoshi, Fukuda Wakako, Fukuda Ikuo, Watanabe Ken-ichi, Saito Yoshiaki, Nakamura Mashio, Sakuma Masahito

机构信息

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

出版信息

Interact Cardiovasc Thorac Surg. 2012 Jan;14(1):64-7. doi: 10.1093/icvts/ivr018. Epub 2011 Nov 15.

Abstract

OBJECTIVE

Massive pulmonary embolism is relatively rare but a potentially life-threatening condition. The purpose of this study was to analyse the outcome of pulmonary embolectomy in registered data from the Japanese Society of Pulmonary Embolism Research (JaSPER).

METHODS

From 1994 to 2006, 1661 cases of acute pulmonary embolism were registered in the JaSPER database. Retrospective analysis of 32 patients undergoing pulmonary embolectomy was conducted. The overall incidence of pulmonary embolectomy was 1.9% [95% confidence interval (CI): 1.8-3.2%]. The mean age of patients was 57 years and 66% were female.

RESULTS

Overall mortality of pulmonary embolectomy was 18.8% [95% CI: 5.2-25.6%]. Most of the patients had massive or submassive pulmonary thromboembolism, and three patients experienced cardiopulmonary arrest before embolectomy. Ten patients received preoperative percutaneous cardiopulmonary bypass, and mortality was 30% in this subgroup.

CONCLUSIONS

Pulmonary embolectomy is an effective therapeutic option for patients with massive or submassive pulmonary embolism. Prompt triage of patients with haemodynamic instability is important.

摘要

目的

大面积肺栓塞相对罕见,但可能危及生命。本研究旨在分析日本肺栓塞研究学会(JaSPER)登记数据中肺栓子切除术的结果。

方法

1994年至2006年期间,1661例急性肺栓塞病例被登记在JaSPER数据库中。对32例行肺栓子切除术的患者进行回顾性分析。肺栓子切除术的总体发生率为1.9%[95%置信区间(CI):1.8 - 3.2%]。患者的平均年龄为57岁,66%为女性。

结果

肺栓子切除术的总体死亡率为18.8%[95%CI:5.2 - 25.6%]。大多数患者患有大面积或次大面积肺血栓栓塞,3例患者在栓子切除术前发生心肺骤停。10例患者接受了术前经皮体外膜肺氧合,该亚组的死亡率为30%。

结论

肺栓子切除术是大面积或次大面积肺栓塞患者的一种有效治疗选择。对血流动力学不稳定的患者进行及时分诊很重要。

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