Melekos M D
Department of Urology, University of Patras School of Medicine, Rio, Greece.
Int Urol Nephrol. 1990;22(3):257-62. doi: 10.1007/BF02550403.
In a prospective study on 81 patients undergoing transrectal needle biopsy of the prostate, the efficacy of prophylaxis in preventing postbiopsy infectious complications was determined. The patients were divided randomly into four groups, and a comparison of the rate of postbiopsy complications in each group was made. In 11 and 17% of the patients in Group A (n = 18) who received povidone-iodine enema alone, bacteriuria and bacteraemia, respectively, occurred. When parenteral piperacillin alone in Group B (n = 22) was administered, the rates of the same complications were 9 and 14%, respectively, while both rates were as low as 4% in Group C (n = 25) when piperacillin in combination with povidone-iodine enema was given. On the other hand, in 31 and 37.5% of the patients in Group D (n = 16), who served as controls, bacteriuria and bacteraemia developed. The study has thus shown that parenteral piperacillin in combination with povidone-iodine enema significantly reduces the incidence of infectious complications associated with transrectal prostatic biopsy.
在一项针对81例接受经直肠前列腺穿刺活检患者的前瞻性研究中，确定了预防措施在预防活检后感染并发症方面的疗效。患者被随机分为四组，并对每组活检后并发症的发生率进行了比较。在仅接受聚维酮碘灌肠的A组（n = 18）中，分别有11%和17%的患者发生菌尿症和菌血症。当B组（n = 22）仅给予静脉注射哌拉西林时，相同并发症的发生率分别为9%和14%，而当C组（n = 25）给予哌拉西林联合聚维酮碘灌肠时，这两种并发症的发生率均低至4%。另一方面，作为对照组的D组（n = 16）中，分别有31%和37.5%的患者发生菌尿症和菌血症。该研究表明，静脉注射哌拉西林联合聚维酮碘灌肠可显著降低经直肠前列腺活检相关感染并发症的发生率。
