人类微生物组计划：从人类基因组学到的经验。
The Human Microbiome Project: lessons from human genomics.
机构信息
Department of Anthropology, University of Oklahoma, Norman, Oklahoma, USA.
出版信息
Trends Microbiol. 2012 Jan;20(1):1-4. doi: 10.1016/j.tim.2011.10.004. Epub 2011 Nov 21.
Abstract
The Human Microbiome Project (HMP) is following in the footsteps of the Human Genome Project (HGP), which will include exciting discoveries, but also potential disappointment and resentment over the lack of medical applications. There is a wiser path for the HMP. This path includes a greater attention to rare variation, an early commitment to an ethical inclusion of indigenous communities, and a recruitment strategy in which medical benefits are de-emphasized.
摘要
人类微生物组计划（HMP）正在追随人类基因组计划（HGP）的脚步，这将包括令人兴奋的发现，但也可能因缺乏医学应用而感到失望和不满。HMP 有一个更明智的选择。这条道路包括更加关注罕见的变异，早期承诺将土著社区纳入其中，并采取一种策略，即淡化医疗福利在招募中的作用。
相似文献
1
The Human Microbiome Project: lessons from human genomics.人类微生物组计划：从人类基因组学到的经验。
Trends Microbiol. 2012 Jan;20(1):1-4. doi: 10.1016/j.tim.2011.10.004. Epub 2011 Nov 21.
2
[Genetics, genomics and medicine].[遗传学、基因组学与医学]
Presse Med. 2012 Jan;41(1):1-2. doi: 10.1016/j.lpm.2011.09.003. Epub 2011 Oct 12.
3
The impact of genomics on pediatric research and medicine.基因组学对儿科研究和医学的影响。
Pediatrics. 2012 Jun;129(6):1150-60. doi: 10.1542/peds.2011-3636. Epub 2012 May 7.
4
IMG/M-HMP: a metagenome comparative analysis system for the Human Microbiome Project.IMG/M-HMP：人类微生物组计划的宏基因组比较分析系统。
PLoS One. 2012;7(7):e40151. doi: 10.1371/journal.pone.0040151. Epub 2012 Jul 5.
5
Genomic Medicine-Progress, Pitfalls, and Promise.基因组医学——进展、陷阱与前景。
Cell. 2019 Mar 21;177(1):45-57. doi: 10.1016/j.cell.2019.02.003.
6
Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics.药物微生物组学：人类微生物组变异对系统药理学和个性化治疗的影响。
OMICS. 2014 Jul;18(7):402-14. doi: 10.1089/omi.2014.0018. Epub 2014 May 2.
7
Emerging genomic technologies and the concept of personalized medicine.新兴的基因组技术与个性化医疗的概念。
Cell Cycle. 2008 Aug;7(15):2278-85. doi: 10.4161/cc.6476. Epub 2008 Jun 23.
8
Host genetic variation and its microbiome interactions within the Human Microbiome Project.人类微生物组计划中的宿主遗传变异及其与微生物组的相互作用。
Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
9
Biodiversity and functional genomics in the human microbiome.人类微生物组中的生物多样性和功能基因组学。
Trends Genet. 2013 Jan;29(1):51-8. doi: 10.1016/j.tig.2012.09.005. Epub 2012 Nov 7.
10
The human microbiome: a hot spot of microbial horizontal gene transfer.人类微生物组：微生物水平基因转移的热点。
Genomics. 2012 Nov;100(5):265-70. doi: 10.1016/j.ygeno.2012.07.012. Epub 2012 Jul 25.
引用本文的文献
1
Translational Implications of The Gut Microbiome in Women with A Benign or Malignant Pelvic Mass.肠道微生物群在患有良性或恶性盆腔肿块女性中的转化意义
Ann Obstet Gynecol. 2025;8(1). Epub 2025 Feb 12.
2
Developing an ethical framework-guided instrument for assessing bias in EHR-based Big Data studies: a research protocol.制定一个基于伦理框架的工具，用于评估基于电子健康记录的大数据研究中的偏差：研究方案。
BMJ Open. 2023 Aug 17;13(8):e070870. doi: 10.1136/bmjopen-2022-070870.
3
Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions.基于工业化梯度的非靶向粪便代谢组学分析揭示了共同代谢物和工业化对粪便微生物组-代谢组相互作用的影响。
mSystems. 2022 Dec 20;7(6):e0071022. doi: 10.1128/msystems.00710-22. Epub 2022 Nov 23.
4
Novel Thermostable Heparinase Based on the Genome of Bacteroides Isolated from Human Gut Microbiota.基于从人类肠道微生物群中分离出的拟杆菌基因组的新型耐热肝素酶。
Foods. 2022 May 18;11(10):1462. doi: 10.3390/foods11101462.
5
Ethical microbiome research with Indigenous communities.与原住民社区合作进行符合伦理的微生物组研究。
Nat Microbiol. 2022 Jun;7(6):749-756. doi: 10.1038/s41564-022-01116-w. Epub 2022 May 16.
6
Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression.结直肠癌中的口腔-肠道微生物群：炎症与免疫抑制
J Inflamm Res. 2022 Feb 4;15:747-759. doi: 10.2147/JIR.S344321. eCollection 2022.
7
Ethical Challenges Posed by Big Data.大数据带来的伦理挑战。
Innov Clin Neurosci. 2020 Oct 1;17(10-12):24-30. eCollection 2020 Oct-Dec.
8
The role of the oral microbiota in chronic non-communicable disease and its relevance to the Indigenous health gap in Australia.口腔微生物群在慢性非传染性疾病中的作用及其与澳大利亚原住民健康差距的关系。
BMC Oral Health. 2020 Nov 16;20(1):327. doi: 10.1186/s12903-020-01308-y.
9
[Research progress on carbohydrate active enzymes of human microbiome].[人类微生物组碳水化合物活性酶的研究进展]
Hua Xi Kou Qiang Yi Xue Za Zhi. 2019 Dec 1;37(6):666-670. doi: 10.7518/hxkq.2019.06.017.
10
Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method.粪便样本中的微生物群落系统发育分析取决于测序深度的组合和 NGS 分析方法的选择。
PLoS One. 2019 Sep 17;14(9):e0222171. doi: 10.1371/journal.pone.0222171. eCollection 2019.
本文引用的文献
1
Antibiotic overuse: Stop the killing of beneficial bacteria.抗生素过度使用：停止对有益细菌的杀灭。
Nature. 2011 Aug 24;476(7361):393-4. doi: 10.1038/476393a.
2
Enterotypes of the human gut microbiome.人类肠道微生物组的肠型。
Nature. 2011 May 12;473(7346):174-80. doi: 10.1038/nature09944. Epub 2011 Apr 20.
3
Charting a course for genomic medicine from base pairs to bedside.为基因组医学绘制从碱基对到床边的路线图。
Nature. 2011 Feb 10;470(7333):204-13. doi: 10.1038/nature09764.
4
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa.通过对欧洲和非洲农村儿童的比较研究揭示饮食对肠道微生物群的影响。
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6. doi: 10.1073/pnas.1005963107. Epub 2010 Aug 2.
5
Forensic identification using skin bacterial communities.利用皮肤细菌群落进行法医鉴定。
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6477-81. doi: 10.1073/pnas.1000162107. Epub 2010 Mar 15.
6
Rare variants create synthetic genome-wide associations.罕见变异导致全基因组关联合成。
PLoS Biol. 2010 Jan 26;8(1):e1000294. doi: 10.1371/journal.pbio.1000294.
7
The human intestinal microbiome: a new frontier of human biology.人类肠道微生物群：人类生物学的一个新前沿。
DNA Res. 2009 Feb;16(1):1-12. doi: 10.1093/dnares/dsn033. Epub 2009 Jan 15.
8
The human microbiome project.人类微生物组计划
Nature. 2007 Oct 18;449(7164):804-10. doi: 10.1038/nature06244.
9
The NCBI dbGaP database of genotypes and phenotypes.美国国立医学图书馆的基因型和表型数据库（NCBI dbGaP）。
Nat Genet. 2007 Oct;39(10):1181-6. doi: 10.1038/ng1007-1181.
10
Grappling with groups: protecting collective interests in biomedical research.应对群体问题：保护生物医学研究中的集体利益
J Med Philos. 2007 Jul-Aug;32(4):321-37. doi: 10.1080/03605310701515419.
Zotero 插件