Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanotechnology, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia, Australia.
Int J Nanomedicine. 2011;6:2083-95. doi: 10.2147/IJN.S24790. Epub 2011 Sep 23.
Hydroxyapatite (HAP) is a widely used biocompatible ceramic in many biomedical applications and devices. Currently nanometer-scale forms of HAP are being intensely investigated due to their close similarity to the inorganic mineral component of the natural bone matrix. In this study nano-HAP was prepared via a wet precipitation method using Ca(NO(3))(2) and KH(2)PO(4) as the main reactants and NH(4)OH as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH was maintained at 9 during the synthesis process. The influence of the thermal treatment was investigated by using two thermal treatment processes to produce ultrafine nano-HAP powders. In the first heat treatment, a conventional radiant tube furnace was used to produce nano-particles with an average size of approximately 30 nm in diameter, while the second thermal treatment used a microwave-based technique to produce particles with an average diameter of 36 nm. The crystalline structure and morphology of all nanoparticle powders produced were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). Both thermal techniques effectively produced ultrafine powders with similar crystalline structure, morphology and particle sizes.
羟基磷灰石（HAP）是一种广泛应用于许多生物医学应用和设备的生物相容性陶瓷。目前，由于纳米级 HAP 与天然骨基质的无机矿物成分非常相似，因此正在对其进行深入研究。在这项研究中，通过使用 Ca(NO3)2 和 KH2PO4 作为主要反应物和 NH4OH 作为沉淀剂在超声辐射下的湿沉淀法制备纳米 HAP。在合成过程中，Ca/P 比设定为 1.67，pH 值保持在 9。通过使用两种热处理工艺来研究热处理的影响，以生产超细微纳米 HAP 粉末。在第一次热处理中，使用常规辐射管式炉产生平均直径约为 30nm 的纳米颗粒，而第二次热处理使用基于微波的技术产生平均直径为 36nm 的颗粒。使用 X 射线衍射（XRD）、场发射扫描电子显微镜（FESEM）、透射电子显微镜（TEM）和傅里叶变换红外光谱（FT-IR）研究了所有纳米颗粒粉末的晶体结构和形态。两种热技术都有效地生产出具有相似晶体结构、形态和粒径的超细粉末。
