Infection and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
Lancet Infect Dis. 2011 Dec;11(12):963-9. doi: 10.1016/S1473-3099(11)70274-2.
WHO has declared obesity to be a global epidemic. Obesity management strategies mainly target behavioural components of the disorder, but are only marginally effective. A comprehensive understanding of the causative factors of obesity might provide more effective management approaches. Several microbes are causatively and correlatively linked with obesity in animals and human beings. If infections contribute to human obesity, then entirely different prevention and treatment strategies and public health policies could be needed to address this subtype of the disorder. Ethical reasons preclude experimental infection of human beings with candidate microbes to unequivocally determine their contribution to obesity. As an alternative, the available information about the adipogenic human adenovirus Ad36 has been used to create a template that can be used to examine comprehensively the contributions of specific candidate microbes to human obesity. Clinicians should be aware of infectobesity (obesity of infectious origin), and its potential importance in effective obesity management.
世界卫生组织已宣布肥胖为全球性流行病。肥胖管理策略主要针对该疾病的行为成分，但效果甚微。全面了解肥胖的致病因素可能提供更有效的管理方法。一些微生物与动物和人类的肥胖有因果关系和相关性。如果感染导致人类肥胖，那么可能需要完全不同的预防和治疗策略以及公共卫生政策来解决这种肥胖亚型。伦理原因禁止用候选微生物对人类进行实验性感染，以明确确定它们对肥胖的贡献。作为替代方法，已经使用有关脂肪形成的人腺病毒 Ad36 的现有信息来创建模板，该模板可用于全面检查特定候选微生物对人类肥胖的贡献。临床医生应该意识到感染性肥胖（感染性肥胖）及其在有效肥胖管理中的潜在重要性。
