B 细胞与自身免疫。
B cells and autoimmunity.
机构信息
Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States.
出版信息
Curr Opin Immunol. 2011 Dec;23(6):721-31. doi: 10.1016/j.coi.2011.10.007. Epub 2011 Nov 24.
Abstract
There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed.
摘要
人们越来越认识到 B 细胞在自身免疫性疾病中的作用，在 T 细胞驱动炎症的自身免疫性疾病中，B 细胞除了在以致病性自身抗体为特征的自身免疫性疾病中发挥重要作用外。本文将对 B 细胞耐受检查点、B 细胞耗竭、BAFF 阻断、调节性 B 细胞和 SIAE/Siglec 途径介导的克隆性无知等方面的最新信息进行综述。
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Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.激活诱导胞嘧啶脱氨酶 (AID) 对于人类 B 细胞耐受是必需的。
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