探索金黄色葡萄球菌的致病途径，以开发疫苗。
Exploring Staphylococcus aureus pathways to disease for vaccine development.
机构信息
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.
出版信息
Semin Immunopathol. 2012 Mar;34(2):317-33. doi: 10.1007/s00281-011-0299-z. Epub 2011 Dec 1.
Abstract
Staphylococcus aureus is a commensal of the human skin or nares and a pathogen that frequently causes skin and soft tissue infections as well as bacteremia and sepsis. Recent efforts in understanding the molecular mechanisms of pathogenesis revealed key virulence strategies of S. aureus in host tissues: bacterial scavenging of iron, induction of coagulation pathways to promote staphylococcal agglutination in the vasculature, and suppression of innate and adaptive immune responses. Advances in all three areas have been explored for opportunities in vaccine design in an effort to identify the critical protective antigens of S. aureus. Human clinical trials with specific subunit vaccines have failed, yet provide important insights for the design of future trials that must address the current epidemic of S. aureus infections with drug-resistant isolates (MRSA, methicillin-resistant S. aureus).
摘要
金黄色葡萄球菌是人体皮肤或鼻腔的共生菌，也是一种病原体，常引起皮肤和软组织感染以及菌血症和败血症。最近在了解发病机制的分子机制方面的努力揭示了金黄色葡萄球菌在宿主组织中的关键毒力策略：细菌摄取铁、诱导凝血途径以促进血管内金黄色葡萄球菌聚集，以及抑制先天和适应性免疫反应。在这三个领域的进展都为疫苗设计提供了机会，以确定金黄色葡萄球菌的关键保护性抗原。针对特定亚单位疫苗的人体临床试验已经失败，但为未来的试验设计提供了重要的见解，这些试验必须解决目前耐药物金黄色葡萄球菌（MRSA，耐甲氧西林金黄色葡萄球菌）感染的流行问题。
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