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Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.影响尤因肉瘤中EWS-FLI1活性的因素
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A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis.斑马鱼尤文肉瘤转基因模型揭示了 EWS-FLI1 肿瘤发生的保守介质。
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Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study group.EWS/Fli1易位各种外显子组合的鉴定：一种针对石蜡包埋组织的优化逆转录聚合酶链反应方法——CWS研究小组的报告
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本文引用的文献

1
Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma development.Let-7a 是 Ewing 肉瘤发生中直接的 EWS-FLI-1 靶标。
PLoS One. 2011;6(8):e23592. doi: 10.1371/journal.pone.0023592. Epub 2011 Aug 10.
2
BLCAP induces apoptosis in human Ewing's sarcoma cells.BLCAP 诱导人尤文肉瘤细胞凋亡。
Exp Biol Med (Maywood). 2011 Sep;236(9):1030-5. doi: 10.1258/ebm.2011.010315. Epub 2011 Aug 15.
3
Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer.西妥昔单抗联合替西罗莫司治疗晚期癌症的 I 期临床试验。
Clin Cancer Res. 2011 Sep 15;17(18):6052-60. doi: 10.1158/1078-0432.CCR-10-2979. Epub 2011 Jul 12.
4
Development of microRNA-145 for therapeutic application in breast cancer.miR-145 用于乳腺癌治疗的应用开发。
J Control Release. 2011 Nov 7;155(3):427-34. doi: 10.1016/j.jconrel.2011.06.026. Epub 2011 Jun 24.
5
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.通过高通量筛选鉴定 EWS-FLI1 致癌转录因子的抑制剂。
J Natl Cancer Inst. 2011 Jun 22;103(12):962-78. doi: 10.1093/jnci/djr156. Epub 2011 Jun 8.
6
A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.尤文肉瘤中涉及 IGF 通路靶向的新型致癌机制，由 EWS/Fli1 调节的 microRNAs 介导。
Oncogene. 2011 Dec 8;30(49):4910-20. doi: 10.1038/onc.2011.197. Epub 2011 Jun 6.
7
Targeting hypoxia in cancer therapy.针对癌症治疗中的缺氧。
Nat Rev Cancer. 2011 Jun;11(6):393-410. doi: 10.1038/nrc3064.
8
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.缺氧诱导因子 1α和 2α的差异缺氧调节。
Mol Cancer Res. 2011 Jun;9(6):757-65. doi: 10.1158/1541-7786.MCR-11-0053. Epub 2011 May 13.
9
YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion.YK-4-279 抑制 ERG 和 ETV1 介导的前列腺癌细胞侵袭。
PLoS One. 2011 Apr 29;6(4):e19343. doi: 10.1371/journal.pone.0019343.
10
Modeling initiation of Ewing sarcoma in human neural crest cells.建立人神经嵴细胞尤文肉瘤的模型。
PLoS One. 2011 Apr 29;6(4):e19305. doi: 10.1371/journal.pone.0019305.

影响尤因肉瘤中EWS-FLI1活性的因素

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

作者信息

Herrero-Martin David, Fourtouna Argyro, Niedan Stephan, Riedmann Lucia T, Schwentner Raphaela, Aryee Dave N T

机构信息

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria.

出版信息

Sarcoma. 2011;2011:352580. doi: 10.1155/2011/352580. Epub 2011 Nov 10.

DOI:10.1155/2011/352580
PMID:22135504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3216314/
Abstract

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.

摘要

尤因肉瘤家族肿瘤（ESFT）的特征是特定的染色体易位，这会产生EWS-ETS嵌合蛋白。这些异常转录因子是ESFT的主要致病驱动因素。阐明影响EWS-ETS表达和/或活性的因素将指导针对这种致命疾病的新型治疗药物的开发。