Ferris J, Cooper S, Roessner K, Hochberg M
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033.
J Rheumatol. 1990 Jul;17(7):880-4.
Serum samples from 129 patients with definite or classic rheumatoid arthritis (RA) were assayed by ELISA for antibodies to denatured bovine type II collagen (dII). All patients had active disease at the time of serum sampling. Anti-dII antibodies were found in 18 (14%) of 129 patients (95% confidence intervals: 8-20%). The only clinical or laboratory feature associated with the presence of anti-dII antibodies was seronegativity for IgM rheumatoid factor (IgM RF): 6 (37.5%) of 16 seronegative patients had anti-dII antibodies vs 12 (10.6%) of the 113 seropositive patients (OR = 5, p less than 0.01). There were no associations of anti-dII antibodies with age, sex, race, disease activity, disease duration, functional class, or the presence of HLA-DR1, DR4, or DQw3 in these patients. Antibodies to type II collagen may have a pathophysiologic role in RA, especially in patients seronegative for RF.
采用酶联免疫吸附测定法（ELISA）检测了129例确诊或典型类风湿性关节炎（RA）患者的血清样本，以检测其抗变性II型牛胶原蛋白（dII）抗体。所有患者在采集血清样本时均患有活动性疾病。129例患者中有18例（14%）检测到抗dII抗体（95%置信区间：8 - 20%）。与抗dII抗体存在相关的唯一临床或实验室特征是IgM类风湿因子（IgM RF）血清阴性：16例血清阴性患者中有6例（37.5%）有抗dII抗体，而113例血清阳性患者中有12例（10.6%）有抗dII抗体（比值比=5，p<0.01）。在这些患者中，抗dII抗体与年龄、性别、种族、疾病活动度、病程、功能分级或HLA - DR1、DR4或DQw3的存在均无关联。II型胶原蛋白抗体可能在类风湿性关节炎中具有病理生理作用，尤其是在RF血清阴性的患者中。
