Aga Khan University, Stadium Road, Karachi, Pakistan.
Exp Parasitol. 2012 Feb;130(2):95-7. doi: 10.1016/j.exppara.2011.11.005. Epub 2011 Nov 28.
Given the remarkable similarities in cellular structure (morphological and ultra-structural features), molecular motility, biochemical physiology, ability to capture prey by phagocytosis and interactions with microbial pathogens, here we pose the question whether Acanthamoeba and macrophages are evolutionary related. This is discussed in the light of evolution and functional aspects such as the astonishing resemblance of many bacteria to infect and multiply inside human macrophages and amoebae in analogous ways. Further debate and studies will determine if Acanthamoeba is an evolutionary ancestor of macrophages. Is this a myth or reality?
鉴于细胞结构（形态和超微结构特征）、分子运动、生化生理学、通过吞噬作用捕获猎物的能力以及与微生物病原体的相互作用方面的显著相似性，我们在这里提出一个问题，即棘阿米巴和巨噬细胞是否具有进化关系。这是在进化和功能方面讨论的，例如许多细菌以类似的方式感染和在人类巨噬细胞和变形虫内繁殖的惊人相似性。进一步的辩论和研究将确定棘阿米巴是否是巨噬细胞的进化祖先。这是一个神话还是现实？
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