Nova Southeastern University, College of Pharmacy, Department of Pharmaceutical Sciences, 3200 South University Dr, Fort Lauderdale, FL 33328, USA.
Expert Opin Drug Deliv. 2012 Jan;9(1):71-89. doi: 10.1517/17425247.2012.641950. Epub 2011 Dec 6.
Considerable advances have been made to hydrogels with the development of faster swelling superporous hydrogels (SPHs). These new-generation hydrogels have large numbers of interconnected pores, giving them the capacity to absorb large amounts of water at an accelerated rate. This gives SPHs the ability to be used in a variety of novel drug delivery applications, such as gastric retention and peroral intestinal delivery of proteins and peptides.
This review focuses on the applications of SPHs for drug transport and targeted drug therapies, as well as the characteristics and historical advancements made to SPH synthesis as it pertains to drug delivery. Manufacturing considerations and challenges that must be overcome are also discussed, such as scale-up, biocompatibility and safety.
Modern SPHs have high swelling and high mechanical strength making them suitable for many diverse pharmaceutical and biomedical applications. However, demonstrative preclinical animal studies still need to be confirmed in human trials, to further address safety issues and confirm therapeutic success when using SPHs as platforms for drug delivery. The focus of forthcoming applications of SPHs is likely to be in the area of oral site-specific delivery and regenerative medicine.
随着快速溶胀超级多孔水凝胶（SPH）的发展，水凝胶技术取得了长足的进步。这些新一代水凝胶具有大量相互连接的孔，使它们能够以更快的速度吸收大量的水。这使得 SPH 能够应用于各种新型药物输送应用中，例如胃滞留和蛋白质和肽的口服肠道输送。
本综述重点介绍了 SPH 在药物输送和靶向药物治疗中的应用，以及与药物输送相关的 SPH 合成的特性和历史进展。还讨论了制造方面的考虑因素和必须克服的挑战，例如放大、生物相容性和安全性。
现代 SPH 具有高溶胀性和高强度，适用于许多不同的药物和生物医学应用。然而，仍需要在人体试验中进一步证实具有代表性的临床前动物研究结果，以进一步解决使用 SPH 作为药物输送平台时的安全性问题，并确认治疗成功。SPH 的未来应用重点可能在口服定位输送和再生医学领域。
