Schrader J, Tebbe U, Borries M, Ruschitzka F, Schoel G, Kandt M, Warneke G, Züchner C, Weber M H, Neu U
Medizinische Universitätskliniken Göttingen.
Klin Wochenschr. 1990 Aug 2;68(15):774-9. doi: 10.1007/BF01647248.
Plasma concentrations of the recently isolated potent vasoconstrictory peptide endothelin were measured in 382 patients. The investigations were performed by means of a sensitive radioimmunoassay specific for Endothelin-1, 2. The results from 110 healthy volunteers displayed a normal range of 44.67 +/- 3.51 pg/ml. Significantly raised levels were found in 33 patients with chronic end-stage renal failure both before and after hemodialysis. In contrast, 35 patients with compensated renal insufficiency did not differ from the normals. Sixty-five patients after kidney transplantation revealed significantly elevated levels, as did 27 patients with acute myocardial infarction, 8 after coronary bypass surgery, and 5 with liver cirrhosis. The mean values of 27 patients with untreated hypertension, 22 with secondary hypertension, of various causes and 16 with coronary artery disease were comparable to the normal population. The values were significantly decreased in 9 pregnant women with hypertension and proteinuria. A marked decline was found in 5 patients with systemic lupus erythematodes, while 20 patients with rheumatoid arthritis demonstrated only a slight decrease. The pathophysiological role of endothelin as a local or circulating hormone in regulating systemic blood pressure or release of other hormones remains to be determined.
对382例患者测定了最近分离出的强效血管收缩肽内皮素的血浆浓度。采用对内皮素-1、2特异的灵敏放射免疫分析法进行研究。110名健康志愿者的结果显示正常范围为44.67±3.51 pg/ml。33例慢性终末期肾衰竭患者在血液透析前后均发现水平显著升高。相比之下，35例代偿性肾功能不全患者与正常人无差异。65例肾移植患者、27例急性心肌梗死患者、8例冠状动脉搭桥手术后患者以及5例肝硬化患者的水平均显著升高。27例未经治疗的高血压患者、22例各种原因所致继发性高血压患者以及16例冠状动脉疾病患者的平均值与正常人群相当。9例患有高血压和蛋白尿的孕妇的值显著降低。5例系统性红斑狼疮患者的值明显下降，而20例类风湿关节炎患者仅略有下降。内皮素作为一种局部或循环激素在调节全身血压或其他激素释放方面的病理生理作用仍有待确定。
