Section of Geriatrics and Palliative Medicine (MC 6098), 5841 S. Maryland Ave., Chicago, IL 60637, USA.
J Am Geriatr Soc. 2012 Jan;60(1):113-7. doi: 10.1111/j.1532-5415.2011.03769.x. Epub 2011 Dec 8.
To compare the association between self-reported moderate to severe pain and frailty.
Cross-sectional analysis of the Canadian Study of Health and Aging Wave 2.
Community.
Representative sample of persons aged 65 and older in Canada.
Pain (exposure) was categorized as no or very mild pain versus moderate or greater pain. Frailty (outcome) was operationalized as the accumulation of 33 possible self-reported health attitudes, illnesses, and functional abilities, subsequently divided into tertiles (not frail, prefrail, and frail). Multivariable logistic regression assessed for the association between pain and frailty.
Of participants who reported moderate or greater pain (35.5%, 1,765/4,968), 16.2% were not frail, 34.1% were prefrail, and 49.8% were frail. For persons with moderate or greater pain, the odds of being prefrail rather than not frail were higher by a factor of 2.52 (95% confidence interval (CI) = 2.13-2.99; P < .001). For persons with moderate or greater pain, the odds of being frail rather than not frail were higher by a factor of 5.52 (95% CI = 4.49-6.64 P < .001).
Moderate or higher pain was independently associated with frailty. Although causality cannot be ascertained in a cross-sectional analysis, interventions to improve pain management may help prevent or ameliorate frailty.
比较自报告的中度至重度疼痛与虚弱之间的关联。
加拿大老龄化研究第 2 波的横断面分析。
社区。
加拿大年龄在 65 岁及以上的代表性样本。
疼痛（暴露）分为无或轻度疼痛与中度或更严重疼痛。虚弱（结局）通过 33 种可能的自我报告的健康态度、疾病和功能能力的累积来操作化，随后分为三分位（不虚弱、虚弱前期和虚弱）。多变量逻辑回归评估疼痛与虚弱之间的关联。
报告有中度或更严重疼痛的参与者中（35.5%，1765/4968），16.2%的人不虚弱，34.1%的人虚弱前期，49.8%的人虚弱。对于有中度或更严重疼痛的人来说，虚弱前期的可能性比不虚弱高 2.52 倍（95%置信区间（CI）为 2.13-2.99；P<.001）。对于有中度或更严重疼痛的人来说，虚弱的可能性比不虚弱高 5.52 倍（95%CI 为 4.49-6.64；P<.001）。
中度或更高程度的疼痛与虚弱独立相关。虽然横断面分析不能确定因果关系，但改善疼痛管理的干预措施可能有助于预防或改善虚弱。
