Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Biosens Bioelectron. 2012 Jan 15;31(1):426-32. doi: 10.1016/j.bios.2011.11.006. Epub 2011 Nov 15.
In the pursuit of more economical electrocatalysts for non-enzymatic glucose sensors, one-dimensional Cu nanowires (Cu NWs) with uniform size distribution and a large aspect ratio (>200) were synthesized by a facile, scalable, wet-chemistry approach. The morphology, crystallinity, and surface property of the as-prepared Cu NWs were examined by SEM, XRD, and XPS, respectively. The electrochemical property of Cu NWs for glucose electrooxidation was thoroughly investigated by cyclic voltammetry. In the amperometric detection of glucose, the Cu NWs modified glassy carbon electrode exhibited an extraordinary limit of detection as low as 35 nM and a wide dynamic range with excellent sensitivity of 420.3 μA cm(-2) mM(-1), which was more than 10,000 times higher than that of the control electrode without Cu NWs. The performance of the developed glucose sensor was also independent to oxygen concentration and free from chloride poisoning. Furthermore, the interference from uric acid, ascorbic acid, acetaminophen, fructose, and sucrose at the level of their physiological concentration were insignificant, indicating excellent selectivity. Finally, good accuracy and high precision for the quantification of glucose concentration in human serum samples implicate the applicability of Cu NWs in sensitive and selective non-enzymatic glucose detection.
为了寻找更经济的非酶葡萄糖传感器用电催化剂，我们采用简单、可扩展的湿化学方法合成了具有均匀尺寸分布和大纵横比（>200）的一维 Cu 纳米线（CuNWs）。通过 SEM、XRD 和 XPS 分别对所制备的 CuNWs 的形貌、结晶度和表面性质进行了研究。通过循环伏安法对 CuNWs 用于葡萄糖电氧化的电化学性能进行了深入研究。在葡萄糖的安培检测中，CuNWs 修饰的玻碳电极表现出超低的检测极限（低至 35 nM）和宽的动态范围，具有优异的灵敏度（420.3 μA cm(-2) mM(-1)），比没有 CuNWs 的对照电极高 10000 倍以上。所开发的葡萄糖传感器的性能也不受氧浓度的影响，且不受氯化物中毒的影响。此外，尿酸、抗坏血酸、对乙酰氨基酚、果糖和蔗糖在其生理浓度水平的干扰可以忽略不计，表明具有出色的选择性。最后，在人血清样本中葡萄糖浓度的定量检测中，CuNWs 表现出良好的准确性和高精度，表明其在灵敏和选择性非酶葡萄糖检测方面具有适用性。
