Bolu Izzet Baysal Mental Health Hospital, 14000 Bolu, Turkey.
J Psychiatr Res. 2012 Mar;46(3):298-302. doi: 10.1016/j.jpsychires.2011.11.016. Epub 2011 Dec 10.
The relationship between major depression and increased platelet activity has been previously stated by several studies. This study sought to test the relationship between mean platelet volume (MPV)--an indicator of platelet activity--and major depression, in an adult Turkish population sample. Respondents were 2286 participants interviewed in a regional survey. The diagnosis of current (one month) major depression was made according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. MPV was measured along with total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, BMI, and waist circumference. Two hundred eighty-nine participants (12.5%) were diagnosed as having major depression. Patients with major depression were found to have increased MPV levels in comparison with participants without depression (p = 0.001). After excluding the subjects with risk factors capable of influencing platelet activity, MPV was still found to be elevated in patients with major depression compared with non-depressed individuals (p < 0.01). Linear regression analysis revealed a significant independent association of major depression with MPV levels (r = 0.123; p = 0.001). According to the findings of this study, increased MPV (or platelet activation) is associated with current (one month) diagnosis of major depression. Future research should investigate the effect of depression treatment on MPV.
几项研究已经表明，重度抑郁症与血小板活性增加之间存在关联。本研究旨在测试平均血小板体积（MPV）——血小板活性的一个指标——与重度抑郁症之间的关系，研究对象为土耳其成年人的一个样本。调查对 2286 名受访者进行了访谈。根据《精神障碍诊断与统计手册》第四版，对当前（一个月）的重度抑郁症进行诊断。同时测量了总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、BMI 和腰围。289 名参与者（12.5%）被诊断为患有重度抑郁症。与无抑郁的参与者相比，患有重度抑郁症的患者的 MPV 水平更高（p = 0.001）。排除可能影响血小板活性的危险因素后，与非抑郁个体相比，重度抑郁症患者的 MPV 仍然升高（p < 0.01）。线性回归分析显示，重度抑郁症与 MPV 水平之间存在显著的独立关联（r = 0.123；p = 0.001）。根据这项研究的结果，MPV（或血小板激活）的增加与当前（一个月）的重度抑郁症诊断有关。未来的研究应该调查抑郁症治疗对 MPV 的影响。
