护盾升起：Tup1-Cyc8 阻遏物复合物阻止辅激活因子募集。
Shields up: the Tup1-Cyc8 repressor complex blocks coactivator recruitment.
机构信息
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA.
出版信息
Genes Dev. 2011 Dec 1;25(23):2429-35. doi: 10.1101/gad.181768.111.
Abstract
The Tup1-Cyc8 complex is responsible for repression of a large and diverse collection of genes in Saccharomyces cerevisiae. The predominant view has been that Tup1-Cyc8 functions as a corepressor, actively associating with regulatory proteins and organizing chromatin to block transcription. A new study by Wong and Struhl in this issue of Genes & Development (pp. 2525-2539) challenges nearly 20 years of models by demonstrating that Tup1-Cyc8 functions primarily as a shield to block DNA-binding proteins from recruiting transcriptional coactivators.
摘要
Tup1-Cyc8 复合物负责抑制酿酒酵母中大量不同的基因。主要观点是 Tup1-Cyc8 作为一种辅阻遏物发挥作用，主动与调节蛋白结合并组织染色质以阻断转录。Wong 和 Struhl 在本期《基因与发育》（第 2525-2539 页）中的一项新研究挑战了近 20 年的模型，表明 Tup1-Cyc8 的主要功能是作为一种屏蔽物，阻止 DNA 结合蛋白招募转录共激活因子。
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