Department of Urology, Putuo District People's Hospital, Shanghai 200060, China.
Asian J Androl. 2012 Mar;14(2):316-9. doi: 10.1038/aja.2011.154. Epub 2011 Dec 12.
This study was designed to investigate the association between immune inflammation and androgen receptor (AR) expression in benign prostatic hyperplasia (BPH). We retrospectively analyzed 105 prostatectomy specimens. An immune inflammation score for each specimen was defined by combining three immunohistochemical markers (CD4, CD8 and CD20). The immunohistochemical markers were CD4 and CD8 for T lymphocytes, CD20 for B lymphocytes and AR antibody for the AR in BPH samples. Rates of CD4, CD8, CD20 and AR expression in BPH were 20 (19.0%), 21 (20.0%), 101 (96.2%) and 48 (45.7%), respectively. Total prostate volume (TPV) was higher in the immune inflammation group than in the non-immune inflammation group (62.7 ml vs. 49.2 ml, t=2.482, P<0.05). Patients in the immune inflammation group had a higher serum prostate-specific antigen (PSA) than those in the non-inflammation group (7.5 ng ml(-1 )vs. 5.4 ng ml(-1), t=2.771, P<0.05). Specifically, the immune inflammation group showed a higher rate of AR expression than the non-inflammation group (56.1% vs. 28.2%, χ(2)=7.665, P<0.05). Our study revealed a strong association between immune inflammation and TPV, serum PSA and AR expression in BPH tissue. Prostate hyperplasia caused by an immune inflammatory process may contribute to BPH progression over time. Therefore, the inflammatory response involved in BPH may be a prime therapeutic target.
这项研究旨在探讨良性前列腺增生（BPH）中免疫炎症与雄激素受体（AR）表达之间的关系。我们回顾性分析了 105 例前列腺切除术标本。通过结合三种免疫组织化学标志物（CD4、CD8 和 CD20），为每个标本定义了一个免疫炎症评分。免疫组织化学标志物分别为 T 淋巴细胞的 CD4 和 CD8、B 淋巴细胞的 CD20 和 BPH 样本中的 AR 抗体。BPH 中 CD4、CD8、CD20 和 AR 的表达率分别为 20（19.0%）、21（20.0%）、101（96.2%）和 48（45.7%）。免疫炎症组的总前列腺体积（TPV）高于非免疫炎症组（62.7 ml 比 49.2 ml，t=2.482，P<0.05）。免疫炎症组患者的血清前列腺特异性抗原（PSA）水平高于非炎症组（7.5 ng ml(-1)比 5.4 ng ml(-1)，t=2.771，P<0.05）。具体而言，免疫炎症组的 AR 表达率高于非炎症组（56.1%比 28.2%，χ(2)=7.665，P<0.05）。我们的研究表明，BPH 组织中的免疫炎症与 TPV、血清 PSA 和 AR 表达之间存在很强的相关性。由免疫炎症过程引起的前列腺增生可能导致 BPH 随时间进展。因此，BPH 中涉及的炎症反应可能是一个主要的治疗靶点。
