Peixoto Andrea P, Campos Gubio S, Queiroz Leila B, Sardi Silvia I
Laboratory of Virology, Department of Biointeraction, Institute of Health Sciences, Federal University of Bahia, Vale do Canela, Brazil.
J Oral Sci. 2011 Dec;53(4):451-9. doi: 10.2334/josnusd.53.451.
The oral route of human papillomavirus (HPV) transmission is not fully understood. It has been suggested that genital infection can act as a reservoir for oral HPV infection. We investigated the presence of oral HPV DNA and anti-HPV IgA in the buccal cavity of patients with a histopathologic diagnosis of cervical HPV infection. One hundred women underwent oral clinical examinations to detect HPV-DNA by polymerase chain reaction and salivary anti-HPV IgA by indirect immunofluorescence. Information on the personal habits of all the women was collected in personal interviews. Our results showed that 99% of the patients had no clinical manifestations of oral HPV. However, HPV DNA was detected in 81% of oral mucosa samples, and anti-HPV IgA was detected in the saliva of 44% of the patients. Consumption of alcoholic beverages was significantly associated with detection of oral HPV DNA and salivary anti-HPV IgA. Other behavioral risk factors associated with oral HPV and anti-HPV IgA are also discussed. In conclusion, patients with genital HPV infection are at risk for subclinical oral HPV infection. Thus, a molecular assay might be necessary to diagnose such infections.
人乳头瘤病毒（HPV）的经口传播途径尚未完全明确。有观点认为，生殖器感染可能是口腔HPV感染的一个来源。我们对经组织病理学诊断为宫颈HPV感染的患者口腔中HPV DNA和抗HPV IgA的存在情况进行了调查。100名女性接受了口腔临床检查，通过聚合酶链反应检测HPV-DNA，并通过间接免疫荧光检测唾液中的抗HPV IgA。通过个人访谈收集了所有女性的个人习惯信息。我们的结果显示，99%的患者没有口腔HPV的临床表现。然而，在81%的口腔黏膜样本中检测到了HPV DNA，在44%的患者唾液中检测到了抗HPV IgA。酒精饮料的摄入与口腔HPV DNA和唾液抗HPV IgA的检测显著相关。还讨论了与口腔HPV和抗HPV IgA相关的其他行为危险因素。总之，生殖器HPV感染患者存在亚临床口腔HPV感染的风险。因此，可能需要一种分子检测方法来诊断此类感染。
