Department of Vision Sciences, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom.
Invest Ophthalmol Vis Sci. 2012 Feb 21;53(2):817-24. doi: 10.1167/iovs.11-8219.
The purpose of the present study was to explore the potential for treating childhood amblyopia with a binocular stimulus designed to correlate the visual input from both eyes.
Eight strabismic, two anisometropic, and four strabismic and anisometropic amblyopes (mean age, 8.5 ± 2.6 years) undertook a dichoptic perceptual learning task for five sessions (each lasting 1 hour) over the course of a week. The training paradigm involved a simple computer game, which required the subject to use both eyes to perform the task.
A statistically significant improvement (t(₁₃) = 5.46; P = 0.0001) in the mean visual acuity (VA) of the amblyopic eye (AE) was demonstrated, from 0.51 ± 0.27 logMAR before training to 0.42 ± 0.28 logMAR after training with six subjects gaining 0.1 logMAR or more of improvement. Measurable stereofunction was established for the first time in three subjects with an overall significant mean improvement in stereoacuity after training (t(₁₃) =2.64; P = 0.02).
The dichoptic-based perceptual learning therapy employed in the present study improved both the monocular VA of the AE and stereofunction, verifying the feasibility of a binocular approach in the treatment of childhood amblyopia.
本研究旨在探索通过设计一种与双眼视觉输入相关的双眼刺激来治疗儿童弱视的可能性。
8 名斜视性、2 名屈光参差性和 4 名斜视性和屈光参差性弱视患者（平均年龄 8.5 ± 2.6 岁）参加了为期一周的五次双眼知觉学习任务（每次持续 1 小时）。训练范式涉及一个简单的电脑游戏，要求受试者用双眼完成任务。
在接受训练的 6 名患者中，有 5 名患者的弱视眼（AE）的平均视力（VA）显著提高（t(₁₃) = 5.46；P = 0.0001），从训练前的 0.51 ± 0.27 logMAR 提高到训练后的 0.42 ± 0.28 logMAR。其中 3 名患者首次建立了可测量的立体功能，整体立体锐度在训练后显著提高（t(₁₃) = 2.64；P = 0.02）。
本研究中采用的基于双眼的知觉学习疗法提高了 AE 的单眼 VA 和立体功能，验证了在儿童弱视治疗中采用双眼方法的可行性。
