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Polymers for gene delivery: Charged for success.

作者信息

Mastrobattista Enrico, Hennink Wim E

出版信息

Nat Mater. 2011 Dec 15;11(1):10-2. doi: 10.1038/nmat3209.

DOI:10.1038/nmat3209

PMID:22169909

Abstract

摘要

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Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery.

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How to screen non-viral gene delivery systems in vitro?

J Control Release. 2011 Sep 25;154(3):218-32. doi: 10.1016/j.jconrel.2011.05.001. Epub 2011 May 7.

Nonviral vectors for gene delivery.

Chem Rev. 2009 Feb;109(2):259-302. doi: 10.1021/cr800409e.

Non-viral is superior to viral gene delivery.

J Control Release. 2007 Nov 20;123(3):181-3. doi: 10.1016/j.jconrel.2007.09.004. Epub 2007 Sep 14.

Gene therapy clinical trials worldwide to 2007--an update.

J Gene Med. 2007 Oct;9(10):833-42. doi: 10.1002/jgm.1100.

Artificial viruses: a nanotechnological approach to gene delivery.

Nat Rev Drug Discov. 2006 Feb;5(2):115-21. doi: 10.1038/nrd1960.

Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers.

J Control Release. 2000 Jul 31;68(1):1-8. doi: 10.1016/s0168-3659(00)00246-7.

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相似文献

Polymers for gene delivery: Charged for success.

Nat Mater. 2011 Dec 15;11(1):10-2. doi: 10.1038/nmat3209.

Polycations for Gene Delivery: Dilemmas and Solutions.

Bioconjug Chem. 2019 Feb 20;30(2):338-349. doi: 10.1021/acs.bioconjchem.8b00688. Epub 2018 Nov 12.

Structure-Function Correlations of Poly(Amido Amine)s for Gene Delivery.

Macromol Biosci. 2017 Mar;17(3). doi: 10.1002/mabi.201600297. Epub 2016 Sep 29.

Amphoteric poly(amido amine)s with adjustable balance between transfection efficiency and cytotoxicity for gene delivery.

Colloids Surf B Biointerfaces. 2019 Mar 1;175:10-17. doi: 10.1016/j.colsurfb.2018.11.045. Epub 2018 Nov 20.

Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange.

J Am Chem Soc. 2001 Sep 5;123(35):8628-9. doi: 10.1021/ja0158455.

In vitro cytotoxicity of poly(amidoamine)s: relevance to DNA delivery.

Biochim Biophys Acta. 1999 Apr 19;1427(2):161-74. doi: 10.1016/s0304-4165(99)00021-5.

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12013-7. doi: 10.1002/anie.201605958. Epub 2016 Aug 19.

Polymers for gene delivery: current status and future perspectives.

Recent Pat DNA Gene Seq. 2012 Aug;6(2):98-107. doi: 10.2174/187221512801327389.

Sequence-defined polymers for the delivery of oligonucleotides.

Nanomedicine (Lond). 2014 Dec;9(18):2843-59. doi: 10.2217/nnm.14.166.

Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems.

Macromol Biosci. 2013 May;13(5):641-9. doi: 10.1002/mabi.201200462. Epub 2013 Mar 19.

引用本文的文献

Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines.

Signal Transduct Target Ther. 2025 Mar 10;10(1):73. doi: 10.1038/s41392-024-02112-8.

A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy.

Adv Sci (Weinh). 2025 Apr;12(13):e2413006. doi: 10.1002/advs.202413006. Epub 2025 Feb 8.

Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage.

Biomacromolecules. 2024 Jul 8;25(7):4177-4191. doi: 10.1021/acs.biomac.4c00283. Epub 2024 Jun 12.

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Front Pharmacol. 2022 Jan 21;12:762362. doi: 10.3389/fphar.2021.762362. eCollection 2021.

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Pharmaceutics. 2021 Nov 19;13(11):1964. doi: 10.3390/pharmaceutics13111964.

Folic Acid/Peptides Modified PLGA-PEI-PEG Polymeric Vectors as Efficient Gene Delivery Vehicles: Synthesis, Characterization and Their Biological Performance.

Mol Biotechnol. 2021 Jan;63(1):63-79. doi: 10.1007/s12033-020-00285-5. Epub 2020 Nov 3.

Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers.

Sci Adv. 2020 May 29;6(22):eaay7148. doi: 10.1126/sciadv.aay7148. eCollection 2020 May.

Non-viral transfection vectors: are hybrid materials the way forward?

Medchemcomm. 2019 Aug 16;10(10):1692-1718. doi: 10.1039/c9md00275h. eCollection 2019 Oct 1.

本文引用的文献

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery.

Nat Mater. 2011 Dec 4;11(1):82-90. doi: 10.1038/nmat3187.

How to screen non-viral gene delivery systems in vitro?

J Control Release. 2011 Sep 25;154(3):218-32. doi: 10.1016/j.jconrel.2011.05.001. Epub 2011 May 7.

Nonviral vectors for gene delivery.

Chem Rev. 2009 Feb;109(2):259-302. doi: 10.1021/cr800409e.

Non-viral is superior to viral gene delivery.

J Control Release. 2007 Nov 20;123(3):181-3. doi: 10.1016/j.jconrel.2007.09.004. Epub 2007 Sep 14.

Gene therapy clinical trials worldwide to 2007--an update.

J Gene Med. 2007 Oct;9(10):833-42. doi: 10.1002/jgm.1100.

Artificial viruses: a nanotechnological approach to gene delivery.

Nat Rev Drug Discov. 2006 Feb;5(2):115-21. doi: 10.1038/nrd1960.

Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers.

J Control Release. 2000 Jul 31;68(1):1-8. doi: 10.1016/s0168-3659(00)00246-7.