使用合成胶原肽控制更高阶组装的组成。
Compositional control of higher order assembly using synthetic collagen peptides.
机构信息
Department of Biochemistry, Robert Wood Johnson Medical School, UMDNJ and the Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.
出版信息
J Am Chem Soc. 2012 Jan 11;134(1):47-50. doi: 10.1021/ja2077894. Epub 2011 Dec 21.
Abstract
We present the case of a two-component collagen peptide hydrogel that self-assembles through noncovalent electrostatic interactions. Natural collagen materials, such as those of connective tissue or the basement membrane, assemble in a hierarchic fashion. Similarly, the synthetic peptides presented here proceed from monomer to trimer to fiber and, finally, to a hydrogel. By varying stoichiometry and concentration, we are able to dissect the stages of higher order assembly. Insight gained from this study will improve the molecular design of biomimetic materials.
摘要
我们介绍了一种由两部分胶原蛋白肽组成的水凝胶，它通过非共价静电相互作用自组装。天然胶原材料，如结缔组织或基底膜的胶原材料，以层次化的方式组装。同样，这里介绍的合成肽从单体到三聚体到纤维，最后到水凝胶。通过改变化学计量和浓度，我们能够剖析更高阶组装的阶段。从这项研究中获得的见解将提高仿生材料的分子设计水平。
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