Avijgan Majid, Meidani Mohsen, Salesi Mansour, Rezaei Farshid
Department of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2011 Oct;2(4):286-90.
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown cause. In this study, we report a case of SLE that was presented with persistent vomiting and liver involvement. To our knowledge, this is the first description of a patient with hepatic necrosis as the initial presentation of SLE in a previously healthy woman without any significant past medical history. In the literature, we found few cases of SLE with liver necrosis. In addition, all the cases found had a past medical history of a missed abortion or other complications of the disease. Therefore, if a young woman presents hepatic necrosis with a background of a previously missed abortion, it is better to perform anti-nuclear antibody (ANA) and anticardiolipin antibody tests as a preventive method for early diagnosis and early treatment.
系统性红斑狼疮（SLE）是一种病因不明的慢性炎症性疾病。在本研究中，我们报告了一例以持续性呕吐和肝脏受累为表现的SLE病例。据我们所知，这是首例在既往健康、无任何重大既往病史的女性中以肝坏死为SLE初始表现的病例描述。在文献中，我们发现SLE合并肝坏死的病例很少。此外，所有已发现的病例都有稽留流产或该疾病其他并发症的既往病史。因此，如果一名年轻女性在既往稽留流产的背景下出现肝坏死，最好进行抗核抗体（ANA）和抗心磷脂抗体检测，作为早期诊断和早期治疗的预防方法。
