State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, PR China.
J Food Sci. 2012 Jan;77(1):M9-14. doi: 10.1111/j.1750-3841.2011.02498.x. Epub 2011 Dec 19.
Lactobacilli have positive effects on bowel microflora and health in humans and animals. In this study, the antagonistic activities of Lactobacillus gasseri Chen, and L. plantarum 18 were assessed by agar plate diffusion assay and tests that determined the growth and urease activity of Helicobacter pylori cocultured with lactobacilli and the adherence of H. pylori to human gastric epithelial cells in the presence of lactobacilli. The results showed that the 2 Lactobacillus strains had significant anti-H.pylori activity, and this activity may be contributed by the cell-free supernatants (CFS) of lactobacilli and live Lactobacillus strains in vitro. The antagonistic activity of the CFS against H. pylori depended on the pH and the presence of metabolites, such as organic acids and proteases. Our results also indicated that 2 Lactobacillus strains could inhibit H. pylori adherence human gastric epithelial cells.
Helicobacter pylori causes chronic gastritis, peptic ulcer disease, and gastric cancer, and it infects about 50% of the world's population. Lactobacilli have been reported to have an inhibitory effect on H. pylori and can be used as probiotic to manufacture dairy products preventing H. pylori infection.
乳杆菌对人类和动物的肠道微生物群和健康有积极影响。在这项研究中，通过琼脂平板扩散法和测试来评估干酪乳杆菌 Chen 和植物乳杆菌 18 的拮抗活性，该测试确定了与乳杆菌共培养的幽门螺杆菌的生长和脲酶活性，以及在存在乳杆菌的情况下幽门螺杆菌对人胃上皮细胞的黏附。结果表明，这 2 株乳杆菌对幽门螺杆菌具有显著的抗活性，这种活性可能是由乳杆菌的无细胞上清液（CFS）和体外的活菌株贡献的。CFS 对幽门螺杆菌的拮抗活性取决于 pH 值和代谢物的存在，如有机酸和蛋白酶。我们的结果还表明，2 株乳杆菌可以抑制幽门螺杆菌黏附人胃上皮细胞。
幽门螺杆菌会导致慢性胃炎、消化性溃疡病和胃癌，它感染了约 50%的世界人口。乳杆菌已被报道对幽门螺杆菌具有抑制作用，并可作为益生菌用于制造乳制品以预防幽门螺杆菌感染。
