乳酸杆菌益生菌对……临床菌株的抗菌活性。 （原文此处不完整）
Antibacterial activity of lactobacilli probiotics on clinical strains of .
作者信息
Rezaee Parastoo, Kermanshahi Rouha Kasra, Falsafi Tahereh
机构信息
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
出版信息
Iran J Basic Med Sci. 2019 Oct;22(10):1118-1124. doi: 10.22038/ijbms.2019.33321.7953.
OBJECTIVES
Treatment of infection by common drugs may be associated with several problems such as antimicrobial resistance to commonly used antibiotics and side effects of employed drugs. Therefore, exploration of non-chemical compounds which are safer than chemical ones is becoming important as an alternative therapy. The purpose of this study was to evaluate the effects of lactic acid bacteria (LAB) against clinical strains of .
MATERIALS AND METHODS
Study of antibacterial effects of LAB against strains included: evaluation of LAB effects as well as its cell-free supernatant (CFS) to reduce the number of , and to examine the effects of CFS to inhibit the urease activity of . The anti-adhesion effect of LAB on adherence of to epithelial cell line was also evaluated.
RESULTS
Evaluation of the anti effect of LAB depended on the strain of and Lactobacillus. However, CFS of LAB reduced significantly the growth of all strains. Also, urease activity of strains was inhibited by CFS of LAB demonstrating that their organic acid may have a role in this inhibition. The significant anti-adhesion effect of LAB on adherence of was also observed.
CONCLUSION
Presence of LAB and/or their CFS can reduce the count of , inhibit the urease activity of , and reduce adhesion of to epithelial cell line. This may be important for the impact of colonization in the host stomach.
目的
使用常用药物治疗感染可能会带来一些问题，如对常用抗生素产生抗微生物耐药性以及所用药物的副作用。因此，探索比化学化合物更安全的非化学化合物作为替代疗法变得越来越重要。本研究的目的是评估乳酸菌（LAB）对……临床菌株的影响。
材料与方法
研究LAB对……菌株的抗菌作用包括：评估LAB及其无细胞上清液（CFS）减少……数量的效果，以及检测CFS抑制……脲酶活性的效果。还评估了LAB对……黏附上皮细胞系的抗黏附作用。
结果
LAB的抗……效果评估取决于……和乳酸杆菌的菌株。然而，LAB的CFS显著降低了所有……菌株的生长。此外，LAB的CFS抑制了……菌株的脲酶活性，表明其有机酸可能在这种抑制中起作用。还观察到LAB对……黏附具有显著的抗黏附作用。
结论
LAB及其CFS的存在可以减少……数量，抑制……的脲酶活性，并减少……对上皮细胞系的黏附。这对于……在宿主胃中定植的影响可能很重要。
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