State Key Laboratory of Food Science, Technology, Jiangnan University, Wuxi 214122, PR China.
J Dairy Sci. 2010 Dec;93(12):5627-34. doi: 10.3168/jds.2010-3449.
Helicobacter pylori may cause stomach diseases such as chronic gastritis, peptic ulcer, and gastric cancer, and several studies reported that lactobacilli have inhibitory effects on H. pylori. In this study, 38 Lactobacillus strains were screened for anti-H. pylori activity using in vitro methods, including survivability under the simulated gastric conditions, agar plate diffusion, urease activity, coaggregation, autoaggregation, and hydrocarbon analysis. The results indicate that 2 Lactobacillus strains showed potential anti-H. pylori activity in vitro. Lactobacillus plantarum 18 had the largest zone of inhibition and markedly reduced the urease activity of H. pylori. Lactobacillus gasseri Chen had higher coaggregation rate (58.15%) and hydrophobicity (59.27%) compared with the other strains. Further research is needed to verify the activities of these strains against H. pylori.
幽门螺杆菌可能导致胃部疾病，如慢性胃炎、消化性溃疡和胃癌，一些研究报道称，乳酸菌对幽门螺杆菌具有抑制作用。在这项研究中，我们使用体外方法筛选了 38 株乳酸菌对幽门螺杆菌的抗活性，包括在模拟胃条件下的存活率、琼脂平板扩散、脲酶活性、共聚、自聚集和烃分析。结果表明，2 株乳酸菌在体外具有潜在的抗幽门螺杆菌活性。植物乳杆菌 18 具有最大的抑菌圈，显著降低了幽门螺杆菌的脲酶活性。与其他菌株相比，干酪乳杆菌 Chen 具有更高的共聚率（58.15%）和疏水性（59.27%）。需要进一步研究来验证这些菌株对幽门螺杆菌的活性。
