Patel Hiren, Thakkar Chintan, Patel Kajal
J Maxillofac Oral Surg. 2010 Sep;9(3):247-50. doi: 10.1007/s12663-010-0103-y. Epub 2010 Nov 27.
Parry-Romberg syndrome or progressive hemifacial atrophy is vary rare, uncommon, degenerative, poorly understood condition characterized by a slow and progressive atrophy affecting one side of the face. The incidence and the causes of this alteration are unknown. Possible factors that are involved in the pathogenesis include disturbance of fat metabolism, trauma, viral infections, heredity, endocrine disturbances and auto-immunity. The most common complications are: trigeminal neuritis, facial paresthesia, severe headache and epilepsy. Characteristically, the atrophy progresses slowly for several years and become stable after certain time period. After stabilization of the disease multi specialty approach including physician, orthodontic treatment and reconstructive surgery with autogenous fat graft can be performed to correct the deformity. The objective of this article is to accomplish a literature review concerning general characteristics, etiology, physiopathology, differential diagnosis and treatment of progressive hemifacial atrophy.
帕里-罗姆伯格综合征或进行性半侧面部萎缩是一种极为罕见、不常见的退行性疾病，其病因尚不清楚，特征为一侧面部缓慢进行性萎缩。这种病变的发病率和病因不明。发病机制中可能涉及的因素包括脂肪代谢紊乱、创伤、病毒感染、遗传、内分泌紊乱和自身免疫。最常见的并发症有：三叉神经炎、面部感觉异常、严重头痛和癫痫。其特点是萎缩会缓慢进展数年，经过一段时间后趋于稳定。疾病稳定后，可采用包括内科医生、正畸治疗以及自体脂肪移植重建手术在内的多专科方法来矫正畸形。本文的目的是对进行性半侧面部萎缩的一般特征、病因、病理生理学、鉴别诊断及治疗进行文献综述。
